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Evolution of the complement system
Current Opinion in Immunology, 2001The mammalian complement system constitutes a highly sophisticated body defense machinery comprising more than 30 components. Research into the evolutionary origin of the complement system has identified a primitive version composed of the central component C3 and two activation proteases Bf and MASP in cnidaria.
Masaru, Nonaka, Fumiko, Yoshizaki
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The complement system and systemic sclerosis
Immunologic Research, 1993Serum concentrations of the various complement components including the classical and the alternative pathways were determined in 58 control healthy subjects and 80 patients with systemic sclerosis (SSC). The mean concentrations of C1q, C2, C5, C6, C7, C9, and factor B were significantly increased in the SSC patients in comparison to controls, while ...
BENBASSAT C +5 more
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A guide to complement biology, pathology and therapeutic opportunity
Nature Reviews Immunology, 2023Dimitrios C Mastellos +2 more
exaly