Results 111 to 120 of about 2,132,131 (391)

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Expressão de proteínas reguladoras do complemento CD55, CD59, CD35 e CD46 na artrite reumatoide Expression of complement regulatory proteins CD55, CD59, CD35, and CD46 in rheumatoid arthritis

Revista Brasileira de Reumatologia, 2011
A artrite reumatoide (AR) é uma doença autoimune, associada à sinovite poliarticular inflamatória, que acomete principalmente as articulações periféricas.
Amanda Kirchner Piccoli, Ana Paula Alegretti, Laiana Schneider, Priscila Schmidt Lora, Ricardo Machado Xavier   +4 more
doaj   +1 more source

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Persistent complement dysregulation with signs of thromboinflammation in active Long Covid

Science
Long Covid is a debilitating condition of unknown etiology. We performed multimodal proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after confirmed severe acute respiratory syndrome coronavirus 2 infection. Analysis of >
Carlo Cervia-Hasler, S. Brüningk, Tobias Hoch, Bowen Fan, Giulia Muzio, Ryan C. Thompson, Laura Ceglarek, Roman Meledin, Patrick Westermann, M. Emmenegger, Patrick Taeschler, Yves Zurbuchen, Michele Pons, D. Menges, T. Ballouz, Sara Cervia-Hasler, Sarah Adamo, Miram Merad, Alexander W. Charney, M. Puhan, P. Brodin, J. Nilsson, Adriano Aguzzi, M. E. Raeber, Christoph B. Messner, N. Beckmann, Karsten M. Borgwardt, O. Boyman   +27 more
semanticscholar   +1 more source

Trogocytosis by Entamoeba histolytica Mediates Acquisition and Display of Human Cell Membrane Proteins and Evasion of Lysis by Human Serum. [PDF]

, 2019
We previously showed that Entamoeba histolytica kills human cells through a mechanism that we termed trogocytosis ("trogo-" means "nibble"), due to its resemblance to trogocytosis in other organisms. In microbial eukaryotes like E.
Miller, Hannah W, Ralston, Katherine S, Suleiman, Rene L   +2 more
core   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

Frontiers in Immunology, 2018
The alternative pathway is a continuously active surveillance arm of the complement system, and it can also enhance complement activation initiated by the classical and the lectin pathways.
Pilar Sánchez-Corral, Richard B. Pouw, Margarita López-Trascasa, Margarita López-Trascasa, Mihály Józsi, Mihály Józsi   +5 more
doaj   +1 more source

PAR1 activation induces the release by Schwann cells of factors promoting cell survival and neuritogenesis [PDF]

, 2017
Protease-activated receptor 1 (PAR1) is a member of a family of four G-protein-coupled receptors which are activated by proteolytic cleavage of their N-terminal extracellular domain.
Artico, M., Ciraci, V., Correani, V., Fabrizi, C., Fumagalli, L., Maras, B., Pompili, E., Schininà, M. E.   +7 more
core  

The serum proteome of Atlantic salmon, Salmo salar, during pancreas disease (PD) following infection with salmonid alphavirus subtype 3 (SAV3) [PDF]

, 2013
Salmonid alphavirus is the aetological agent of pancreas disease (PD) in marine Atlantic salmon, Salmo salar, and rainbow trout, Oncorhynchus mykiss, with most outbreaks in Norway caused by SAV subtype 3 (SAV3).
Akaike, Bayne, Bayne, Bendixen, Bratland, C. Wallace, Castric, Christie, D. Cockerill, D.A. Graham, Eckersall, Ellis, Forné, Fringuelli, Gerwick, Graham, Graham, Graham, Halver, Hara, Hirayama, Holland, J. Tinsley, Jansen, Johnston, Józsi, Kent, Kongtorp, Lorenzen, M. Braceland, M.F. Mcloughlin, Magnadóttir, Martínez, McLoughlin, McLoughlin, McVicar, Meri, Mohri, Munro, Murphy, Nakao, Nelson, P.D. Eckersall, Poppe, R. Bickerdike, R.J. Burchmore, Raynard, Rodger, Rodrigues, Russell, Stafford, Stafford, Tsoi, Villarroel, W. Weir, Weston, Whyte, Wicher, Yamaji   +58 more
core   +1 more source