Results 111 to 120 of about 533,270 (282)

Thinking inside the box: intracellular roles for complement system proteins come into focus. [PDF]

Br J Cancer, 2023
O'Brien RM, Lynam-Lennon N, Olcina MM.
europepmc   +1 more source

IMMUNOLOGICAL STUDIES OF THE 11S PROTEIN COMPONENT OF THE HUMAN COMPLEMENT SYSTEM [PDF]

, 1964
Jane H. Morse, Charles L. Christian
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

The human factor H protein family – an update

Frontiers in Immunology
Complement is an ancient and complex network of the immune system and, as such, it plays vital physiological roles, but it is also involved in numerous pathological processes.
Noémi Sándor, Noémi Sándor, Andrea E. Schneider, Alexandra T. Matola, Veronika H. Barbai, Dániel Bencze, Hani Hashim Hammad, Alexandra Papp, Dorottya Kövesdi, Dorottya Kövesdi, Barbara Uzonyi, Barbara Uzonyi, Mihály Józsi, Mihály Józsi   +13 more
doaj   +1 more source

Complement Nomenclature—Deconvoluted

Frontiers in Immunology, 2019
In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas of ambiguity, and here we propose solutions to resolve these remaining issues. To enable rapid
Suzanne S. Bohlson, Peter Garred, Claudia Kemper, Andrea J. Tenner   +3 more
doaj   +1 more source

INTERACTIONS OF C-REACTIVE PROTEIN WITH THE COMPLEMENT SYSTEM [PDF]

, 1974
J N Siegel, Rosemarie Rent, H Gewurz
openalex   +1 more source

Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution

, 2019
The surface of proteins is heterogeneous with sophisticated but precise hydrophobic and hydrophilic patches, which is essential for their diverse biological functions.
Andreozzi, P., Chakrabortty, S., D’Alicarnasso, M., Frank, L., Hammer, B., Kreppel, F., Krol, S., Kuan, S., Landfester, K., Li, L., Liu, W., Müllen, K., Pelliccia, M., Simon, J., Stellacci, F., Wagner, J., Weil, T., Wu, Y.   +17 more
core   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Characterization of three monoclonal antibodies to membrane co-factor protein (MCP) of the complement system and quantification of MCP by radioassay [PDF]

, 1991
S-W Cho, T J Oglesby, B-L. HSI, Elizabeth M. Adams, John Atkinson   +4 more
openalex   +1 more source