Results 141 to 150 of about 2,113,685 (392)

Two Mosquito LRR Proteins Function as Complement Control Factors in the TEP1-Mediated Killing of Plasmodium [PDF]

, 2009
SummaryPlasmodium development within Anopheles mosquitoes is a vulnerable step in the parasite transmission cycle, and targeting this step represents a promising strategy for malaria control.
Baxter, Richard H.G., Blandin, Stéphanie A., Chelliah, Yogarany, Fraiture, Malou, Frolet, Cécile, Hoffmann, Jules A., Levashina, Elena A., Quispe-Tintaya, Wilber, Steinert, Stefanie   +8 more
core   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

mGPfusion: Predicting protein stability changes with Gaussian process kernel learning and data fusion [PDF]

arXiv, 2018
Proteins are commonly used by biochemical industry for numerous processes. Refining these proteins' properties via mutations causes stability effects as well. Accurate computational method to predict how mutations affect protein stability are necessary to facilitate efficient protein design.
arxiv  

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

idMotif: An Interactive Motif Identification in Protein Sequences [PDF]

idMotif: An Interactive Motif Identification in Protein Sequences," in IEEE Computer Graphics and Applications, 2023
This article introduces idMotif, a visual analytics framework designed to aid domain experts in the identification of motifs within protein sequences. Motifs, short sequences of amino acids, are critical for understanding the distinct functions of proteins. Identifying these motifs is pivotal for predicting diseases or infections.
arxiv   +1 more source

Ig-binding surface proteins of Streptococcus pyogenes also bind human C4b-binding protein (C4BP), a regulatory component of the complement system.

Journal of Immunology, 1995
Streptococcus pyogenes, an important human pathogen, expresses several proteins that interact with the immune system of the host. Among the proteins isolated from different bacterial strains are antiphagocytic M proteins, Ig Fc-binding proteins and ...
A. Thern, L. Stenberg, B. Dahlbäck, G. Lindahl   +3 more
semanticscholar   +1 more source

Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study [PDF]

, 2022
Background: Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which are key components of innate immunity, as ...
Bocchetta, Martina, Bouzigues, Arabella, Butler, Chris, Cash, David, Danek, Adrian, Dopper, Elise G.P., Ducharme, Simon, Finger, Elizabeth, Gerhard, Alexander, Graff, Caroline, Heller, Carolin, Jiskoot, Lize C., Laforce, Robert, Masellis, Mario, McFall, David, Meeter, Lieke H., Moreno, Fermin, Panman, Jessica L., Papma, Janne M., Peakman, Georgia, Poos, Jackie M., Rowe, James B., Sanchez-Valle, Raquel, Sogorb-Esteve, Aitana, Swift, Imogen J., Synofzik, Matthis, Tartaglia, Maria Carmela, Todd, Emily, van der Ende, Emma L., Vandenberghe, Rik   +29 more
core   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Analysis of Plasma Proteins Involved in Inflammation, Immune Response/Complement System, and Blood Coagulation upon Admission of COVID-19 Patients to Hospital May Help to Predict the Prognosis of the Disease [PDF]

, 2023
Daniele Castro di Flora, Aline Dionízio, Heloísa Aparecida Barbosa Silva Pereira, Thais Francini Garbieri, Larissa Tercília Grizzo, Thiago José Dionísio, Aline de Lima Leite, Lícia C. Silva-Costa, Nathalia Rabelo Buzalaf, Fernanda Navas Reis, Virgínia Bodelão Richini‐Pereira, Déborah Maciel Cavalcanti Rosa, Carlos Ferreira Santos, Marília Afonso Rabelo Buzalaf   +13 more
openalex   +1 more source

Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome

Clinical Diagnostic Laboratory Immunology, 1996
The systemic inflammatory response of the body to invading microorganisms, termed sepsis, leads to profound activation of the complement system. Pathophysiological concepts suggest that complement activation occurs very early in this syndrome. Thus, we discuss whether the determination of concentrations of the complement components C3a, C5a, and C3 in ...
Andreas Klos, S Stöve, T Welte, Axel Kola, Jörg Köhl, Wilfried Bautsch, T O Wagner   +6 more
openaire   +3 more sources