Sequence-based prediction of function site and protein-ligand interaction by a functionally annotated domain profile database [PDF]
arXiv, 2017 Identifying protein functional sites (PFSs) and protein-ligand interactions (PLIs) are critically important in understanding the protein function and the involved biochemical reactions. As large amount of unknown proteins are quickly accumulated in this post-genome era, an urgent task arises to predict PFSs and PLIs at residual level.
arxiv
Cell-Based High-Throughput Screening Assay System for Monitoring G Protein-Coupled Receptor Activation Using β-Galactosidase Enzyme Complementation Technology [PDF]
, 2002 Yu-Xin Yan +7 more
openalex +1 more source
Decoding multicellular interaction networks–a new horizon in tumor microenvironment research
Molecular Oncology, Volume 19, Issue 4, Page 957-960, April 2025.Cells in the tumor microenvironment influence tumor establishment and progression through an elaborate array of cellular interactions. Integrating transcriptomic, spatial, and intercellular crosstalk data at single‐cell resolution unveil complex, functionally distinct multicellular circuits.
Roi Balaban, Merav Cohen
wiley +1 more source
The Kaposi's Sarcoma-associated Herpesvirus Complement Control Protein Mimics Human Molecular Mechanisms for Inhibition of the Complement System [PDF]
, 2004 Linda Mark +6 more
openalex +1 more source
Complement function and expression in the red-tailed phascogale (Phascogale calura) [PDF]
, 2016 The complement system is found in both invertebrates and vertebrates, and functions in both innate and adaptive immune responses. This thesis involves determining the presence of a complement system in non-eutherian mammals using publicly available non ...
Ong, Oselyne T.
core
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Models of chromosome architecture and connection with the regulation of genetic expression [PDF]
arXiv, 2018 Increasing evidence suggests that chromosome folding and genetic expression are intimately connected. For example, the co-expression of a large number of genes can benefit from their spatial co-localization in the cellular space. Furthermore, functional structures can result from the particular folding of the chromosome.
arxiv
Dynamic control of the complement system by modulated expression of regulatory proteins [PDF]
, 2010 Joshua M. Thurman, Brandon Renner
openalex +1 more source
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan +6 more
wiley +1 more source