Results 71 to 80 of about 2,103,871 (307)
Frontiers in Immunology, 2016 The complement system plays an important role in the innate and acquired immune response against pathogens. It consists of more than 30 proteins found in soluble form or attached to cell membranes. Most complement proteins circulate in inactive forms and
Lourdes eIsaac, Ana Catarina Lunz Macedo
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On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni. [PDF]
PLoS Neglected Tropical Diseases, 2013 It is believed that schistosomes evade complement-mediated killing by expressing regulatory proteins on their surface. Recently, six homologues of human CD59, an important inhibitor of the complement system membrane attack complex, were identified in the
Leonardo P Farias +11 more
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A typical workflow to simulate cytoskeletal systems with Cytosim [PDF]
Journal of ovisualized experiments, 2022, 2022 Many cytoskeletal systems are now sufficiently well known to permit their precise quantitative modelling. Microtubule and actin filaments are well characterized, and the associated proteins are often known, as well as their abundance and the interactions between these elements.
arxiv
Overview of Complement Activation and Regulation [PDF]
, 2013 SummaryComplement is an important component of the innate immune system that is crucial for defense from microbial infections and for clearance of immune complexes and injured cells.
Noris, Marina, Remuzzi, Giuseppe
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Complement system activation in obstructive sleep apnea
Journal of Sleep Research, 2018 The complement system may play a role in the systemic inflammation characterising obstructive sleep apnea; however, this has not been investigated before.
P. Horváth +7 more
semanticscholar +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
The effect of splenectomy on complement regulatory proteins in erythrocytes in β-thalassemia major
Archives of Medical Science, 2018 Introduction Hemolysis due to ineffective erythropoiesis is a serious problem β-thalassemia major (β-TM) patients. The role of complement system in the etiopathogenesis of hemolysis observed in β-TM were released.
Ayşegül Uğur Kurtoğllu +3 more
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Surface antibody changes protein corona both in human and mouse serum but not final opsonization and elimination of targeted polymeric nanoparticles [PDF]
, 2023 Background: Nanoparticles represent one of the most important innovations in the medical field. Among nanocarriers, polymeric nanoparticles (PNPs) attracted much attention due to their biodegradability, biocompatibility, and capacity to increase efficacy
Bertoncin, Paolo +9 more
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Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes [PDF]
, 2015 Specific co-chaperone adaptors facilitate the recruitment of client proteins to the Hsp90 system. Tah1 binds the C-terminal conserved MEEVD motif of Hsp90, thus linking an eclectic set of client proteins to the R2TP complex for their assembly and ...
Ali +42 more
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