Results 81 to 90 of about 325,997 (305)
Sites of Production of Primate Serum Proteins Associated with the Complement System.
Experimental Biology and Medicine, 1967 SummaryVarious human and monkey tissues, including liver, spleen, bone marrow, and lung were found to incorporate C14-amino acids into 11S globulin (C′1q) in vitro. A comparison with previous studies on β10 (C′3) and 1β1E (C′4) production revealed a striking similarity in the sites of synthesis of these 3 proteins.
Stecher, V. J. +2 more
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Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Complement System in the Pathogenesis of Benign Lymphoepithelial Lesions of the Lacrimal Gland. [PDF]
PLoS ONE, 2016 We aimed to examine the potential involvement of local complement system gene expression in the pathogenesis of benign lymphoepithelial lesions (BLEL) of the lacrimal gland.We collected data from 9 consecutive pathologically confirmed patients with BLEL ...
Jing Li +4 more
doaj +1 more source
MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation [PDF]
The Journal of Immunology, 2009 Abstract Essential effector functions of innate immunity are mediated by complement activation initiated by soluble pattern recognition molecules: mannan-binding lectin (MBL) and the ficolins. We present a novel, phylogenetically conserved protein, MAp44, which is found in human serum at 1.4 μg/ml in Ca2+-dependent complexes with the ...
Degn, Søren Egedal; id_orcid 0000-0001-5409-045X +5 more
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Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage
, 2015 Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Rocha-Ferreira, E +5 more
core +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System
Frontiers in Immunology, 2020 The complement system has developed different strategies to clear infections by several effector mechanisms, such as opsonization, which supports phagocytosis, attracting immune cells by C3 and C5 cleavage products, or direct killing of pathogens by the ...
Zahra Malekshahi +5 more
doaj +1 more source
COMPLEMENT SYSTEM PROTEIN C4 AND SUSCEPTIBILITY TO HYDRALAZINE-INDUCED SYSTEMIC LUPUS ERYTHEMATOSUS
The Lancet, 1989 21 patients with systemic lupus erythematosus induced by long-term treatment with hydralazine were investigated to see whether susceptibility to this syndrome was associated with deficiency of the classical pathway complement protein, C4. 16 of 21 (76%) patients had one or more C4 null (ie, non-productive) alleles compared with 35 of 82 normal subjects
Speirs, C +4 more
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In vivo protein stabilization based on fragment complementation and a split GFP system [PDF]
Proceedings of the National Academy of Sciences, 2010 Protein stabilization was achieved through in vivo screening based on the thermodynamic linkage between protein folding and fragment complementation. The split GFP system was found suitable to derive protein variants with enhanced stability due to the correlation between effects of mutations on the stability of the intact chain and the effects of the ...
Stina, Lindman +4 more
openaire +2 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source