Results 81 to 90 of about 327,401 (305)

The The Interplay of Complements and their Regulators in the Human Body

Journal of Microbiological Sciences
An infection can be viewed as a battle between invading pathogen and the host. The complement system represents an evolutionarily conserved component of innate immunity designed to manage this ongoing conflict.
Rao Muhammad Abid Khan, Muneeba Musharraf, Saima Javed, Hira Jamil, Muhammad Shaheen Iqbal, Faiz Muhammad, Muhammad Yaseen, Kulsoom Kazmi   +7 more
doaj   +1 more source

Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

Frontiers in Immunology, 2018
The alternative pathway is a continuously active surveillance arm of the complement system, and it can also enhance complement activation initiated by the classical and the lectin pathways.
Pilar Sánchez-Corral, Richard B. Pouw, Margarita López-Trascasa, Margarita López-Trascasa, Mihály Józsi, Mihály Józsi   +5 more
doaj   +1 more source

The Kaposi's Sarcoma-associated Herpesvirus Complement Control Protein Mimics Human Molecular Mechanisms for Inhibition of the Complement System [PDF]

Journal of Biological Chemistry, 2004
Kaposi's sarcoma-associated human herpesvirus (KSHV) is thought to cause Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Previously, we reported that the KSHV complement control protein (KCP) encoded within the viral genome is a potent regulator of the complement system; it acts both as a cofactor for factor I and ...
Mark, Linda, Lee, Wen H, Spiller, O Brad, Proctor, David, Blackbourn, David J, Villoutreix, Bruno O, Blom, Anna M   +6 more
openaire   +3 more sources

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The Complement System: A Prey of Trypanosoma cruzi

Frontiers in Microbiology, 2017
Trypanosoma cruzi is a protozoan parasite known to cause Chagas disease (CD), a neglected sickness that affects around 6–8 million people worldwide. Originally, CD was mainly found in Latin America but more recently, it has been spread to countries in ...
Kárita C. F. Lidani, Iara J. de Messias-Reason, Lorena Bavia, Altair R. Ambrosio   +3 more
doaj   +1 more source

Sites of Production of Primate Serum Proteins Associated with the Complement System.

Experimental Biology and Medicine, 1967
SummaryVarious human and monkey tissues, including liver, spleen, bone marrow, and lung were found to incorporate C14-amino acids into 11S globulin (C′1q) in vitro. A comparison with previous studies on β10 (C′3) and 1β1E (C′4) production revealed a striking similarity in the sites of synthesis of these 3 proteins.
Stecher, V. J., Morse, J. H., Thorbecke, G. J.   +2 more
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Complement Evasion Strategies of Viruses: An Overview

Frontiers in Microbiology, 2017
Being a major first line of immune defense, the complement system keeps a constant vigil against viruses. Its ability to recognize large panoply of viruses and virus-infected cells, and trigger the effector pathways, results in neutralization of viruses ...
Palak Agrawal, Renuka Nawadkar, Hina Ojha, Jitendra Kumar, Arvind Sahu   +4 more
doaj   +1 more source

MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation [PDF]

The Journal of Immunology, 2009
Abstract Essential effector functions of innate immunity are mediated by complement activation initiated by soluble pattern recognition molecules: mannan-binding lectin (MBL) and the ficolins. We present a novel, phylogenetically conserved protein, MAp44, which is found in human serum at 1.4 μg/ml in Ca2+-dependent complexes with the ...
Degn, Søren Egedal; id_orcid 0000-0001-5409-045X, Hansen, Annette, Steffensen, Rudi, Jacobsen, Christian, Jensenius, Jens C, Thiel, Steffen; id_orcid 0000-0002-4817-155X   +5 more
openaire   +3 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source