Results 81 to 90 of about 547,306 (324)
Advances in the design and development of oncolytic measles viruses. [PDF]
, 2015 A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian +2 more
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Sites of Production of Primate Serum Proteins Associated with the Complement System.
Experimental Biology and Medicine, 1967 SummaryVarious human and monkey tissues, including liver, spleen, bone marrow, and lung were found to incorporate C14-amino acids into 11S globulin (C′1q) in vitro. A comparison with previous studies on β10 (C′3) and 1β1E (C′4) production revealed a striking similarity in the sites of synthesis of these 3 proteins.
Stecher, V. J. +2 more
openaire +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Frontiers in Immunology, 2018 The alternative pathway is a continuously active surveillance arm of the complement system, and it can also enhance complement activation initiated by the classical and the lectin pathways.
Pilar Sánchez-Corral +5 more
doaj +1 more source
Equine recurrent uveitis - A spontaneous horse model of uveitis [PDF]
, 2008 Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis.
Altmann, Frank +8 more
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Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
The Complement System: A Prey of Trypanosoma cruzi
Frontiers in Microbiology, 2017 Trypanosoma cruzi is a protozoan parasite known to cause Chagas disease (CD), a neglected sickness that affects around 6–8 million people worldwide. Originally, CD was mainly found in Latin America but more recently, it has been spread to countries in ...
Kárita C. F. Lidani +3 more
doaj +1 more source
Complement System in the Pathogenesis of Benign Lymphoepithelial Lesions of the Lacrimal Gland. [PDF]
PLoS ONE, 2016 We aimed to examine the potential involvement of local complement system gene expression in the pathogenesis of benign lymphoepithelial lesions (BLEL) of the lacrimal gland.We collected data from 9 consecutive pathologically confirmed patients with BLEL ...
Jing Li +4 more
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Secreted Autotransporter Toxin (Sat) Mediates Innate Immune System Evasion
Frontiers in Immunology, 2022 Several strategies are used by Escherichia coli to evade the host innate immune system in the blood, such as the cleavage of complement system proteins by secreted proteases.
Claudia A. Freire +9 more
doaj +1 more source
The pathophysiology of the complement system in leprosy [PDF]
, 1991 The complement system, which consists of a group of proteins and glycoproteins, generally serves to amplify the effects of the interaction of antigen with antibody.
Ramanathan, V D
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