The Role of Apoptosis Proteins and Complement Components in the Etiopathogenesis of Systemic Lupus Erythematosus [PDF]
Clinics, 2010 Systemic lupus erythematosus is a prototypical autoimmune disease characterized by the deregulation of T and B cells, tissue infiltration by mononuclear cells, tissue damage and the production of autoantibodies. There is a consensus that accelerated apoptosis of circulating lymphocytes and/or impaired clearance of apoptotic bodies may increase the ...
Liphaus, Bernadete L. +1 more
openaire +5 more sources
Frontiers in Immunology, 2018 The complement system is a tightly regulated network of proteins involved in defense against pathogens, inflammatory processes, and coordination of the innate and adaptive immune responses.
Cecilie E. Hertz +6 more
doaj +1 more source
Systems Biology Modeling of the Complement System Under Immune Susceptible Pathogens
Frontiers in Physics, 2021 The complement system is assembled from a network of proteins that function to bring about the first line of defense of the body against invading pathogens.
Nehemiah T. Zewde +4 more
doaj +1 more source
Learning Geometrically Disentangled Representations of Protein Folding Simulations [PDF]
arXiv, 2022 Massive molecular simulations of drug-target proteins have been used as a tool to understand disease mechanism and develop therapeutics. This work focuses on learning a generative neural network on a structural ensemble of a drug-target protein, e.g. SARS-CoV-2 Spike protein, obtained from computationally expensive molecular simulations.
arxiv
Biomarkers of the Complement System in Cancer. [PDF]
Medeni Med JObjective: Cancer is a disease characterized by an unregulated division of abnormal cells in the body. The discovery of oncogenes and tumor suppressor genes has paved the way for the targeted use of individual biomarkers and proteins in cancer therapy ...
Kubat Oktem E.
europepmc +2 more sources
Two Mosquito LRR Proteins Function as Complement Control Factors in the TEP1-Mediated Killing of Plasmodium [PDF]
, 2009 SummaryPlasmodium development within Anopheles mosquitoes is a vulnerable step in the parasite transmission cycle, and targeting this step represents a promising strategy for malaria control.
Baxter, Richard H.G. +8 more
core +1 more source
Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response [PDF]
, 2014 Exposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein content of bronchoalveolar lavage (BAL) and lung tissue.
Floros, Joanna +7 more
core +1 more source
Same but not alike: Structure, flexibility and energetics of domains in multi-domain proteins are influenced by the presence of other domains [PDF]
PLoS Computational Biology, Public Library of Science, 2018, 14
(2), pp.e1006008, 2018 The majority of the proteins encoded in the genomes of eukaryotes contain more than one domain. Reasons for high prevalence of multi-domain proteins in various organisms have been attributed to higher stability and functional and folding advantages over single-domain proteins.
arxiv +1 more source
Cartilage oligomeric matrix protein-induced complement activation in systemic sclerosis [PDF]
Arthritis Research & Therapy, 2013 Abstract Introduction Complexes between cartilage oligomeric matrix protein (COMP) and the complement activation product C3b have been found in the circulation of patients with rheumatoid arthritis and systemic lupus erythematosus.
Dick Heinegård +5 more
openaire +3 more sources
The Complement System of Agnathans
Frontiers in Immunology, 2018 Agnathans (lamprey and hagfish) are a group of primitive jawless fish. Jawed vertebrates possess adaptive immunity including immunoglobulins, while agnathans lack immunoglobulins but have alternative adaptive immunity in which variable lymphocyte ...
M. Matsushita
semanticscholar +1 more source