Results 161 to 170 of about 898,423 (293)

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

<i>norCBD</i> disruption affects the H2-type six secretion system and multiple virulence factors in <i>Pseudomonas aeruginosa</i>. [PDF]

Front Microbiol
Haque MM, Badr S, Duan K.
europepmc   +1 more source

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

Nature Genetics, 2005
A. R. Meetei, A. Medhurst, Chen Ling, Yutong Xue, T. R. Singh, Patrick Bier, Jûrgen Steltenpool, S. Stone, I. Dokal, C. Mathew, M. Hoatlin, H. Joenje, J. Winter, Weidong Wang   +13 more
semanticscholar   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Synergistic regulatory mechanisms in glycolysis revealed by pathway transplantation. [PDF]

mBio
Knibbe E, Boonekamp FJ, Stuij R, Savakis P, Pelsma KAJ, Jansen L, Flores C-L, Teusink B, Daran-Lapujade P.   +8 more
europepmc   +1 more source

hCTR1: a human gene for copper uptake identified by complementation in yeast.

Proceedings of the National Academy of Sciences of the United States of America, 1997
Bing Zhou, J. Gitschier
semanticscholar   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Evaluating Pretrained Protein Language Model Embeddings as Proxies for Functional Similarity. [PDF]

J Mol Evol
Shaw R, Love SD, McWhite CD.
europepmc   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

A broadly applicable split-luciferase biosensor approach for rapid antibody detection in emerging infectious diseases. [PDF]

Appl Microbiol Biotechnol
Li X, Niu Q, Wang J, Chai Y, Zou X, Sun H, Yin H, Dou S, Guan G, Yang J.   +9 more
europepmc   +1 more source