Results 101 to 110 of about 616,916 (268)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Genome analysis of a Glossina pallidipes salivary gland hypertrophy virus reveals a novel, large, double-stranded circular DNA virus

, 2008
Several species of tsetse flies can be infected by the Glossina pallidipes salivary gland hypertrophy virus (GpSGHV). Infection causes salivary gland hypertrophy and also significantly reduces the fecundity of the infected flies. To better understand the
Parker, Andrew G., Robinson, Alan S., Abd-Alla, A.M.M., Cousserans, F., Vlak, J.M., Cousserans, Francois, F., Jehle, Johannes A., Bergoin, Max, Parker, A.G., Bergoin, M., Abd-Alla, Adly M. M., Vlak, Just M., Jehle, J.A., Parker, N.J., Robinson, A.S., Parker, Nicolas J.   +15 more
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Genome sequence reveals that Pseudomonas fluorescens F113 possesses a large and diverse array of systems for rhizosphere function and host interaction [PDF]

, 2013
Background: Pseudomonas fluorescens F113 is a plant growth-promoting rhizobacterium (PGPR) isolated from the sugar-beet rhizosphere. This bacterium has been extensively studied as a model strain for genetic regulation of secondary metabolite production ...
María Sánchez-Contreras, Rivilla Palma, Rafael, Germaine, Kieran, O’Gara, Fergal, Dowling, David N., David Dowling, Sánchez-Contreras, María, Ana Navazo, Rafael Rivilla, Candela, Muriel, Martínez-Granero, Francisco, Barahona, Emma, Martinez-Granero, F., Emma Barahona, Fergal, O´Gara, Francisco Martínez-Granero, Martín, M., Redondo Nieto, Miguel, Morrissey, John P., Sánchez-Contreras, M., Candela Muriel, Barret, M., Moynihan, J., Martín Basanta, Marta, Germaine, K., Barahona, E., Navazo, A., John Morrissey, Jennifer A Moynihan, Sánchez-Contrerasa, María, Dowling, D., Moynihan, Jennifer A., Miguel Redondo-Nieto, Martín, Marta, Navazo, Ana, Morrissey, John, O\u27Gara, Fergal, Moynihan, Jennifer A, Muriel, C., Fergal O’Gara, Barret, Matthieu, Matthieu Barret, Rivilla, Rafael, Moynihan, Jennifer, Morrissey, J., Redondo-Nieto, M., Kieran Germaine, Marta Martín, Redondo-Nieto, Miguel, Rivilla, R., Muriel, Candela, Germaine, Kieran J., Dowling, David, O'Gara, Fergal   +53 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Complete mitochondrial genome sequence of Lichtheimia ramosa (syn. Lichtheimia hongkongensis)

, 2014
We report the complete mitochondrial genome sequence of Lichtheimia ramosa (syn. Lichtheimia hongkongensis), the first complete mitochondrial DNA sequence of the genus Lichtheimia.
Woo, PCY, Huang, Y, Leung, SY, Lau, Susanna K.P., Huang, Yi, Lau, SKP, Woo, Patrick C.Y., Leung, Shui Yee   +7 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

The complete chloroplast genome sequence of pomegranate ‘Bhagwa’

Mitochondrial DNA. Part B. Resources, 2019
Pomegranate (Punica granatum), as one of the most important fruit trees, is widely cultivated in the tropical and subtropical of the world. In our present study, we assembled a complete chloroplast genome of an important pomegranate cultivar ‘Bhagwa ...
Ming Yan, Xueqing Zhao, Yujie Zhao, Yuan Ren, Zhaohe Yuan   +4 more
doaj   +1 more source

Genome Sequence of a Recently Emerged, Highly Transmissible, Multi-Antibiotic- and Antiseptic-Resistant Variant of Methicillin-Resistant Staphylococcus aureus, Sequence Type 239 (TW)

, 2010
The Sanger Institute is core funded by the Wellcome Trust. Funding for the sequencing of the TW20 genome was provided by Guy’s and St. Thomas’ Charity. J.D.E.
Edgeworth, Jonathan D., Quail, MA, Bentley, SD, Quail, Michael A., Parkhill, Julian, Corton, C, Parkhill, J, Lindsay, JA, Lindsay, Jodi A., Edgeworth, JD, Pathak, Smriti, Batra, R, Pathak, S, Bentley, Stephen D., Holden, MT, Holden, Matthew T. G., Cockfield, Joshua D., Batra, Rahul, Cockfield, JD, Corton, Craig   +19 more
core   +1 more source

The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay [PDF]

, 2008
This work was partly supported by grants from The Research Council of Norway and the University of Tromsø.Background: The fish pathogen Aliivibrio salmonicida is the causative agent of cold-water vibriosis in marine aquaculture.
Parkhill Julian, Paulsen, Steinar, Thomson Nicholas R, Lorentzen, Marit Sjo, Sanders, Suzanne, Quail, Michael A., Norbertczak, Halina, Thurston, Scott, Erik Hjerde, Holden, Matthew TG, Hjerde Erik, Suzanne Sanders, Holden, Matthew T. G., Sanders Suzanne, Julian Parkhill, Seeger, Kathy, Lorentzen Marit, Norbertczak Halina, Bason Nathalie, Thurston Scott, Quail Michael A, David Harris, Paulsen Steinar, Michael A Quail, Quail, Michael A, Matthew TG Holden, Steinar Paulsen, Hjerde, Erik, Parkhill, Julian, Harris David, Seeger Kathy, Kathy Seeger, Scott Thurston, Nathalie Bason, Holden Matthew TG, Carol Churcher, Willassen, Nils Peder, Bason, Nathalie, Churcher, Carol, Marit Lorentzen, Halina Norbertczak, Thomson, Nicholas R, Thomson, Nicholas R., Nils Willassen, Harris, David, Nicholas R Thomson, Churcher Carol, Willassen Nils   +47 more
core   +1 more source