Results 91 to 100 of about 4,988,905 (265)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Genome analysis of a Glossina pallidipes salivary gland hypertrophy virus reveals a novel, large, double-stranded circular DNA virus [PDF]

, 2008
Several species of tsetse flies can be infected by the Glossina pallidipes salivary gland hypertrophy virus (GpSGHV). Infection causes salivary gland hypertrophy and also significantly reduces the fecundity of the infected flies. To better understand the
Parker, Andrew G., Robinson, Alan S., Abd-Alla, A.M.M., Cousserans, F., Vlak, J.M., Cousserans, Francois, F., Jehle, Johannes A., Bergoin, Max, Parker, A.G., Bergoin, M., Abd-Alla, Adly M. M., Vlak, Just M., Jehle, J.A., Parker, N.J., Robinson, A.S., Parker, Nicolas J.   +15 more
core   +1 more source

Complete chloroplast genome sequence of Ampelocalamus scandens (Arundinarodae)

Mitochondrial DNA. Part B. Resources, 2020
Ampelocalamus scandens is native to Guizhou Province, China, and grows at an altitude of 260–320 m. It can be used as a raw material for weaving and papermaking. In the current study, the complete chloroplast (cp) genome of A.
Lili Fan, Yangyang Zhang, Muhammad Waqqas Khan Tarin, Tianyou He, Jundong Rong, Yushan Zheng   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Complete genome sequence of the fire blight pathogen Erwinia pyrifoliae DSM 12163(T) and comparative genomic insights into plant pathogenicity [PDF]

, 2010
Smits THM, Jaenicke S, Rezzonico F, et al. Complete genome sequence of the fire blight pathogen Erwinia pyrifoliae DSM 12163(T) and comparative genomic insights into plant pathogenicity. BMC Genomics.
Smits, Theo H. M., Kamber, Tim, Sebastian Jaenicke, Goesmann, Alexander ; https://orcid.org/, Theo HM Smits, Fabio Rezzonico, Rezzonico, Fabio, Jaenicke, Sebastian, Frey, Jürg E, Duffy, Brion, Tim Kamber, Jürg E Frey, Brion Duffy, Alexander Goesmann   +13 more
core   +1 more source

The complete chloroplast genome sequence of Xylosma congesta

Mitochondrial DNA. Part B. Resources, 2019
We sequenced and analyzed the complete chloroplast genome of Xylosma congesta. The chloroplast genome was 156,520 bp in size, containing a large single-copy (84,404 bp) and a small single-copy region (16,474 bp) separated by two inverted repeat regions ...
Yang Tian, Shuyu Liu, Yi Li, Jianguo Zhang, Zhaoshan Wang   +4 more
doaj   +1 more source

The complete chloroplast genome sequence of Artemisia ordosica

Mitochondrial DNA. Part B. Resources, 2020
The complete chloroplast genome sequence of Artemisia ordosica was characterized from Illumina pair-end sequencing. The chloroplast genome of A. ordosica was 151,209 bp in length, containing a large single-copy region (LSC) of 80,975 bp, a small single ...
Xiang Li, Jinhuan He, Yanxian Lian, Fengling Li, Jianghua Suo, Guoqian Jin   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The individual and common repertoire of DNA-binding transcriptional regulators of Corynebacterium glutamicum, Corynebacterium efficiens, Corynebacterium diphtheriae and Corynebacterium jeikeium deduced from the complete genome sequences [PDF]

, 2005
Brune I, Brinkrolf K, Kalinowski J, Pühler A, Tauch A. The individual and common repertoire of DNA-binding transcriptional regulators of Corynebacterium glutamicum, Corynebacterium efficiens, Corynebacterium diphtheriae and Corynebacterium jeikeium ...
Brune, Iris, Brinkrolf, Karina, Tauch, Andreas, Kalinowski, Jörn, Pühler, Alfred ; https://orcid.org/   +4 more
core   +1 more source

The complete chloroplast genome sequence of Zanthoxylum armatum

Mitochondrial DNA. Part B. Resources, 2019
The first complete chloroplast genome sequences of Zanthoxylum armatum were reported in this study. The cpDNA of Z. armatum is 158,579 bp in length, contains a large single copy region (LSC) of 85,780 bp and a small single copy region (SSC) of 17,598 bp,
Yi Wang, Jiabo Hao, Xiaolong Yuan, Yongkang Sima, Bin Lu   +4 more
doaj   +1 more source