Results 81 to 90 of about 397,867 (315)

Signed Complete Graphs with Maximum Index

open access: yesDiscussiones Mathematicae Graph Theory, 2020
Let Γ = (G, σ) be a signed graph, where G is the underlying simple graph and σ E(G) → {−, +} is the sign function on the edges of G. The adjacency matrix of a signed graph has −1 or +1 for adjacent vertices, depending on the sign of the edges.
Akbari Saieed   +3 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Some Properties of the Nil-Graphs of Ideals of Commutative Rings

open access: yesپژوهش‌های ریاضی, 2022
Let R be a commutative ring with identity and Nil(R) be the set of nilpotent elements of R. The nil-graph of ideals of R is defined as the graph AG_N(R) whose vertex set is {I:(0)and there exists a non-trivial ideal  such that  and two distinct vertices  
Reza Nikandish
doaj  

DIMENSI METRIK KETETANGGAAN LOKAL GRAF HASIL OPERASI k-COMB

open access: yesContemporary Mathematics and Applications (ConMathA), 2019
Research on the local adjacency metric dimension has not been found in all operations of the graph, one of them is comb product graph. The purpose of this research was to determine the local adjacency metric dimension of k-comb product graph and level ...
Fryda Arum Pratama   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy