Results 91 to 100 of about 9,924,949 (260)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Phase III Trial: Single Low-Dose 5 mg Dexamethasone with NEPA for Preventing 168 h Nausea and Vomiting of Diverse Highly or Moderately Emetogenic Chemotherapy (LD-NEPA)

Diseases
Background/Objectives: Reducing corticosteroid exposure has become an important objective in the management of chemotherapy-induced nausea and vomiting (CINV), given the dose-related toxicity of dexamethasone (DEX). This prospective phase III randomized (
Yuting He, Xintian Huang, Kaiyi Rong, Yongxiang Hong, Fanzhuoran Lou, Bowen Zheng, Weijuan Tan, Quan Chen, Huibo Shi, Li Xiao   +9 more
doaj   +1 more source

Pathological complete response.

, 2015
Pathological complete response.
Muneharu Konishi (833445), Kazuhiko Yamagami (833443), Daishu Miura (833440), Tomoyuki Kubota (833449), Yoshie Hasegawa (394398), Seung Jin Kim (833442), Takashi Ishikawa (206896), Masaru Miyashita (833444), Masato Suzuki (833447), Yasushi Shigeoka (833446), Jun Horiguchi (833439), Tetsuya Taguchi (833448), Hirokazu Tanino (833438), Norio Kohno (833450), Shintaro Takao (833441), Mitsuhiro Hayashi (679464), Kouhei Akazawa (15187)   +16 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Conversion therapy for advanced hepatocellular carcinoma following complete response to transarterial radioembolization combined with atezolizumab and bevacizumab

Radiology and Oncology
The current Barcelona Clinic Liver Cancer (BCLC) classification recommends systemic treatment with atezolizumab and bevacizumab as the first-line therapy for advanced hepatocellular carcinoma (HCC).
Popovic Peter, Kalamutova Ana, Djokic Mihajlo, Cuderman Anka, Boltezar Gasper, Trotovsek Blaz   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Climax magazine of November 22, 1989 vol.2, no.17: the ultimate in pleasurable reading [PDF]

, 1989
This is the climax magazine of November 22, 1989 vol.2, no.17.• Tony St. lyke dated married producer while living with Stella Monye. • Miss Nigeria, Adewunmi Adebowale, booted out of Lagos State University (LASU). • Why Oliver de Coque eats bones, by his
COMPLETE Communications limited
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Significance of Early Proton Beam Therapy Initiation in Achieving Complete Response in Pediatric Medulloblastoma: A Retrospective Study

Cancer Medicine
Introduction Proton beam therapy (PBT) has proven to be highly effective in treating pediatric medulloblastoma, offering both excellent therapeutic outcomes and reduced side effects. However, factors influencing tumor response following PBT remain poorly
Zhipeng Shen, Zhuo Hou, Wei Han, Yi Zhang, Weiling Zhang, Shuihua Wu, Jianfeng Liang, Chen Jiang, Zishen Wang, Wei Wang, Shuyan Zhang, Hideyuki Sakurai, Shosei Shimizu (Qingshui Xiangxing)   +12 more
doaj   +1 more source