Results 81 to 90 of about 9,924,949 (260)

Controversies and Perspectives in the Current Management of Patients with Locally Advanced Rectal Cancer—A Systematic Review

Life
Traditionally, the therapeutic approach to rectal cancer has involved neoadjuvant chemoradiotherapy followed by surgical resection, and, in some cases, adjuvant chemotherapy.
Roxana Elena Stefan, Rodica Daniela Birla, Mircea Gheorghe, Daniela Elena Dinu, Petre Angel Hoara, Diana Ciuc, Valeriu-Gabi Dinca, Silviu Constantinoiu   +7 more
doaj   +1 more source

Complete response of a metastatic gastroesophageal adenocarcinoma on irinotecan-based chemotherapy in a dialysis patient

, 2010
J Verwimp1, F Geurs1, S Ponette2, J Ponette2, J Martens3, K Bulté21Department of Medical Oncology, 2Department of Gastroenterology, 3Department of Nephrology, Regionaal Ziekenhuis Sint-Maria, Ziekenhuislaan, Halle, BelgiumAbstract: We present ...
et al, F Geurs, S Ponette, J Verwimp
core  

A central review of histopathology reports after breast cancer neoadjuvant chemotherapy in the neo-tango trial [PDF]

, 2013
Background: Neo-tAnGo, a National Cancer Research Network (NCRN) multicentre randomised neoadjuvant chemotherapy trial in early breast cancer, enroled 831 patients in the United Kingdom.
K Walland, N Fenwick, M Iddawela, E Provenzano, Walland, K., Abraham, J. (Janet), Grier, Anna, L Hiller, J Abraham, A Grier, Fenwick, Nicola, Bowden, S. (Sarah), Iddawela, M., Caldas, C., H M Earl, R Champ, S Bowden, J Dunn, Vallier, A. -L., Champ, R., Earl, Helena M., C Caldas, Dunn, Janet A., Hiller, Louise, A-L Vallier, Provenzano, E.   +25 more
core   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

David Slays Goliath: Exceptional Efficacy of Oral Vinorelbine in Conquering Metastatic Finger Angiosarcoma

Journal of Cancer Research and Practice
Angiosarcoma (AS) is a rare and aggressive disease originating from blood or lymphatic vessel endothelium, representing
Te-Lin Hsu, San-Chi Chen
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Connecticut State Emergency Response Commission [web site] [Harvested on 2011: Jun. 1]

, 2011
Updated irregularly; Began in 2002?; Title from home page (publisher's Web site, viewed June 1, 2011).; At head of title: State of Connecticut.; Official website of the Connecticut State Emergency Response Commission.

core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Case Report: Complete response to the novel NaPi2b-targeting ADC YL205 in heavily pretreated platinum-resistant ovarian cancer

Frontiers in Oncology
ObjectivesHigh-grade serous ovarian carcinoma (HGSOC) remains a formidable challenge in the platinum-resistant setting (PROC). In the post-PARP inhibitor (PARPi) era, prior exposure reshapes resistance mechanisms, necessitating a shift from traditional ...
Yan-Xiang Tang, Hui Xiao, Zhen-Zi Tang, Lian Jian, Xingzi Guo   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source