Results 31 to 40 of about 6,409,647 (168)

Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. [PDF]

, 2010
Kaposi's sarcoma (KS) is the most common cancer among HIV-positive patients. Histogenetic origin of KS has long been elusive due to a mixed expression of both blood and lymphatic endothelial markers in KS tumor cells.
Kafka, Darren, Koh, Chester J., Aguilar Berenice, Yoo, Jaehyuk, Hong Young-Kwon, Hong, Young-Kwon, Lee, Sunju, Choi, Inho, Yoo Jaehyuk, Haas, Jürgen G., Kang Jinjoo, Lee Ha Neul, Swapnika Ramu, Kang, Jinjoo, Young-Kwon Hong, Juneyong Lee, Ramu, Swapnika, Darren Kafka, Lee, Juneyong, Kafka Darren, Lee Sunju, Choi Inho, Juergen Haas, Haas, Juergen, Lee Juneyong, Sunju Lee, Inho Choi, Ha Neul Lee, Haas Juergen, Aguilar, Berenice, Chester J. Koh, Jinjoo Kang, Chester J Koh, Jaehyuk Yoo, Koh Chester J., Berenice Aguilar, Ramu Swapnika, Lee, Ha Neul   +37 more
core   +1 more source

A Role for All-Trans-Retinoic Acid in the Early Steps of Lymphatic Vasculature Development [PDF]

, 2010
The molecular mechanisms that regulate the earliest steps of lymphatic vascular system development are unknown. To identify regulators of lymphatic competence and commitment, we used an in vitro vascular assay with mouse embryonic stem cell-derived ...
Dabouras, Vasilios, Marino, Daniela, Vasilios Dabouras, Detmar, Michael, Braendli, Andre W., Michael Detmar, André W. Brändli, Daniela Marino, Brändli AW, Marino D, Dabouras V, Detmar M   +11 more
core   +1 more source

Venous Thromboembolism in Pediatric Vascular Anomalies

Frontiers in Pediatrics, 2017
The presence of a vascular anomaly suggests that capillaries, veins, arteries, and/or lymphatic vessels have demonstrated abnormal development and growth.
Taizo A. Nakano, Chadi Zeinati
doaj   +1 more source

Mutations in EPHB4 cause human venous valve aplasia

JCI Insight, 2021
Venous valve (VV) failure causes chronic venous insufficiency, but the molecular regulation of valve development is poorly understood. A primary lymphatic anomaly, caused by mutations in the receptor tyrosine kinase EPHB4, was recently described, with ...
Oliver Lyons, James Walker, Christopher Seet, Mohammed Ikram, Adam Kuchta, Andrew Arnold, Magda Hernández-Vásquez, Maike Frye, Gema Vizcay-Barrena, Roland A. Fleck, Ashish S. Patel, Soundrie Padayachee, Peter Mortimer, Steve Jeffery, Siren Berland, Sahar Mansour, Pia Ostergaard, Taija Makinen, Bijan Modarai, Prakash Saha, Alberto Smith   +20 more
doaj   +1 more source

Pathogenic variant in EPHB4 results in central conducting lymphatic anomaly

, 2018
Central conducting lymphatic anomaly (CCLA) is one of the complex lymphatic anomalies characterized by dilated lymphatic channels, lymphatic channel dysmotility and distal obstruction affecting lymphatic drainage. We performed whole exome sequencing (WES)
Rosetta Chiavacci, Renata Pellegrino da Silva, Maxim Itkin, Cuiping Hou, Wenger, Tara, Itkin, Maxim, Nora Robinson, Robinson, Nora, Kao, Charlly, Hakonarson, Hakon, Bhoj, Elizabeth, Christoph Seiler, Charlly Kao, Dong Li, Lifeng Tian, Gutiérrez Uzquiza, Álvaro, Chiavacci,Rosetta, Hou, Cuiping, Behr, Mechenzie, Sleiman, Patrick, Hakon Hakonarson, Liu, Yichuan, Yoav Dori, Alvaro Gutierrez-Uzquiza, Mechenzie Behr, Wang, Tiancheng, Patrick Sleiman, Dori, Yoav, Marina Bakay, Michael A Levine, March, Michael, Michael E March, Rosenbach, Misha, Yichuan Liu, Tara L Wenger, Levine, Michael, Seiler, Christoph, Misha Rosenbach, Jonathan A Perkins, Bakay, Marina, Elizabeth Bhoj, Tiancheng Wang, Patricia J Hicks, Li, Dong, Hicks, Patricia, Pellegrino da Silva, Renata, Tian, Lifeng, Perkins, Jonathan   +47 more
core   +1 more source

Fibro-adipose vascular anomaly (FAVA): three case reports with an emphasis on the mammalian target of rapamycin (mTOR) pathway

Diagnostic Pathology, 2020
Background Fibro-adipose vascular anomaly (FAVA) is a new entity of vascular anomalies with somatic and mosaic gain-of-function mutations of the phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA). PIK3CA mutation excessively
Yumiko Hori, Katsutoshi Hirose, Noriko Aramaki-Hattori, Sachi Suzuki, Robert Nakayama, Masanori Inoue, Takahiro Matsui, Masaharu Kohara, Satoru Toyosawa, Eiichi Morii   +9 more
doaj   +1 more source

Sirolimus is efficacious in treatment for extensive and/or complex slow-flow vascular malformations: a monocentric prospective phase II study

Orphanet Journal of Rare Diseases, 2018
Background Extensive and complex vascular malformations often cause chronic pain and severe functional restraint. Conventional treatments, such as surgery and/or sclerotherapy, are rarely curative, underscoring the great need for new therapeutic ...
Jennifer Hammer, Emmanuel Seront, Steven Duez, Sophie Dupont, An Van Damme, Sandra Schmitz, Claire Hoyoux, Caroline Chopinet, Philippe Clapuyt, Frank Hammer, Miikka Vikkula, Laurence M. Boon   +11 more
doaj   +1 more source

Expansion of the Phenotype of Lymphatic Anomalies Caused by Somatic Activating BRAF Variant. [PDF]

Pediatr Blood Cancer
Fox MD, Kumar S, Britt AD, Srinivasan AS, Surrey LF, Vatsky SE, Borst AJ, Hakonarson H, Li D, Sheppard SE, Snyder KM, Adams DM.   +11 more
europepmc   +2 more sources

Targeted Therapy for Complex Lymphatic Anomalies in Patients with Noonan Syndrome and Related Disorders [PDF]

International Journal of Molecular Sciences
Recent diagnostic advances reveal that lymphatic disease in Noonan syndrome (NS) and other NS-like RASopathies often stems from central conducting lymphatic anomalies (CCLAs). The RAS/MAPK-ERK pathway plays a central role in lymphangiogenesis. Targeting this pathway with MEK-inhibitor trametinib has emerged as a promising therapeutic strategy for ...
Leenders, E.K.S.M., van den Brink, V.C., Kleimeier, Lotte E.R., Woutersen, D.T.J., Coppens, C.H., den Hertog, J., Klein, W.M., Rinne, T.K., Vrancken, S.L., de Wildt, S.N., de Wildt, S.N., Draaisma, J.M.T., Fuijkschot, J.   +12 more
openaire   +3 more sources

Tumor-induced myeloid cell plasticity toward lymphatic endothelium [PDF]

, 2009
Tumor-associated lymphangiogenesis contributes to tumor progression by regulating interstitial fluid pressure, transporting immune cells to the tumor site and providing a route for metastatic dissemination.
Baeriswyl, Vanessa
core   +1 more source