Complex lymphatic anomalies: Challenging diagnostic considerations
Clinical Case Reports, 2023 Key Clinical MessageDiagnosis of complex lymphatic anomalies can be difficult, and biopsies can be associated with significant morbidity. Mediastinal masses with features such as osseous involvement warrant thorough noninvasive evaluation prior to biopsy.
Venkatraman Kothandaraman +2 more
openaire +4 more sources
Simple Lymphangioma to Generalized Lymphatic Anomaly: Role of Imaging in Disclosure of a Rare and Morbid Disease [PDF]
Case Reports in Radiology, 2015 Generalized lymphatic anomaly is a rare multisystem congenital disorder in which multiple organs are involved. Imaging features often overlap with other complex lymphatic anomalies and diagnosis is difficult.
Manoj Joshi, Dilip S. Phansalkar
doaj +2 more sources
Challenging diagnosis of Kaposiform lymphangiomatosis: Unveiling a rare primary lymphatic disorder
Radiology Case ReportsKaposiform lymphangiomatosis (KLA) is a rare and complex lymphatic anomaly associated with substantial morbidity and mortality. It features diffuse and multifocal malformed lymphatic channels, often leading to diagnostic difficulties due to its uncommon ...
Rafael Ospino, BS, Claire Brookmeyer, MD
doaj +2 more sources
Central conducting lymphatic anomaly: from bench to bedside
The Journal of Clinical InvestigationCentral conducting lymphatic anomaly (CCLA) is a complex lymphatic anomaly characterized by abnormalities of the central lymphatics and may present with nonimmune fetal hydrops, chylothorax, chylous ascites, or lymphedema.
Luciana Daniela Garlisi Torales +6 more
doaj +2 more sources
SHOC2 Is a Novel Cause of Central Conducting Lymphatic Anomaly. [PDF]
Am J Med Genet ACentral conducting lymphatic anomaly (CCLA) is a devastating disorder where precision medicine can be lifesaving. Diagnosing CCLA is challenging due to its broad spectrum of symptoms, including nonimmune fetal hydrops, chylothorax, chylous ascites, or ...
Ding JC +14 more
europepmc +2 more sources
Neonatal Generalized Lymphatic Anomaly with Skin Involvement. [PDF]
, 2021 Generalized lymphatic anomaly (GLA) is a rare congenital disorder of lymphatic development, presenting with multiple lymphatic malformations in different organs and tissues.
Djuricic, Slavisa +5 more
core +1 more source
Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function
Frontiers in Cell and Developmental Biology, 2023 Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. We and others recently reported that somatic activating mutations in KRAS can cause CLAs.
Lorenzo M. Fernandes +7 more
doaj +1 more source
The Lymphatic Endothelial Cell Secretome Inhibits Osteoblast Differentiation and Bone Formation
Cells, 2023 Complex lymphatic anomalies (CLAs) are a set of rare diseases with unique osteopathic profiles. Recent efforts have identified how lymphatic-specific somatic activating mutations can induce abnormal lymphatic formations that are capable of invading bone ...
Ernesto Solorzano +8 more
doaj +1 more source
Trametinib Inhibits Lymphatic Vessel Invasion of Bone in a Mouse Model of Gorham-Stout Disease
Journal of Vascular Anomalies, 2023 Objective:. Gorham-Stout disease (GSD) is a rare lymphatic anomaly that can be caused by somatic activating mutations in KRAS. This discovery has led investigators to suggest that MEK inhibitors could be a novel treatment for GSD.
Anna L. McCarter, Michael T. Dellinger
doaj +1 more source
Lymphatic malformations: a 9-year experience at the vascular anomaly clinic
Egyptian Pediatric Association Gazette, 2023 Purpose To share our experience in the management of a specific type of vascular malformations (lymphatic) at a specialized multidisciplinary clinic for vascular anomalies.
Amr Abdelhamid AbouZeid +7 more
doaj +1 more source