Complex Lymphatic Anomaly Presenting with Chylothorax, Chylous Ascites, and Generalized Subcutaneous Edema in a Young Cat: Comparative Insights Based on the Human ISSVA Classification [PDF]
Veterinary SciencesIn human medicine, the 2025 International Society for the Study of Vascular Anomalies (ISSVA) classification distinguishes localized lymphatic malformations from systemic disorders referred to as complex lymphatic anomalies (CLAs), including generalized ...
Kazuyuki Terai +6 more
doaj +6 more sources
Case Report: 3 cases of abdominal lesions with lower limb lymphedema—rare mutations in complex lymphatic anomalies [PDF]
Frontiers in OncologyComplex lymphatic anomalies (CLAs) are rare vascular anomalies characterized by abnormal proliferation of lymphatic and blood vessels, often resulting in multisystem involvement with heterogeneous clinical manifestations.
Yujia Zhang +8 more
doaj +6 more sources
Targeted treatment in complex lymphatic anomaly: a case of synergistic efficacy of trametinib and sirolimus [PDF]
Orphanet Journal of Rare DiseasesRepurposing anticancer drugs to vascular malformations has significantly improved patient outcomes. Complex Lymphatic Anomalies (CLA) are part of the spectrum of lymphatic malformations (LMs) that share similar oncogenic mutations to cancer.
Emmanuel Seront +7 more
doaj +4 more sources
Unmasking the invisible: Complex lymphatic anomaly uncovered by bilateral chylothorax
RareComplex lymphatic anomalies (CLA) are an extremely rare group of disorders resulting from embryogenic lymphatic malformations that are characterized by overlapping clinical, anatomic location, imaging features, and complications.
H. Ikrou +11 more
doaj +4 more sources
Osteopathy in Complex Lymphatic Anomalies
International Journal of Molecular Sciences, 2022 Complex Lymphatic Anomalies (CLA) are lymphatic malformations with idiopathic bone and soft tissue involvement. The extent of the abnormal lymphatic presentation and boney invasion varies between subtypes of CLA. The etiology of these diseases has proven to be extremely elusive due to their rarity and irregular progression.
Fayez F Safadi +2 more
exaly +3 more sources
Clinical and CT imaging features of different types of thoracic complex lymphatic anomaly. [PDF]
Quant Imaging Med SurgComplex lymphatic anomaly is a type of lymphatic malformation involving multiple organs and systems, and its clinical and imaging manifestations are varied. The aim of this study was to retrospectively analyze the clinical and imaging features of conventional computed tomography (CT) and CT lymphangiography in patients with thoracic complex lymphatic ...
Zhang Y +5 more
europepmc +3 more sources
Reproductive considerations in patients undergoing treatment for complex lymphatic anomalies. [PDF]
J Vasc Anom (Phila)Complex lymphatic anomalies (CLAs) are a spectrum of lymphatic malformations affecting multiple organ systems. These disorders are characterized by a wide variability in presentation features, which often delays accurate diagnosis and complicates characterization and differentiation.
Vest AN +9 more
europepmc +4 more sources
RAS–PI3Kα signaling regulates KrasG12D-induced lymphangiogenesis in complex lymphatic anomalies [PDF]
Disease Models & MechanismsLorenzo M. Fernandes +5 more
doaj +2 more sources
Detection of NRAS Mutation in Kaposiform Lymphangiomatosis Using Cell-free DNA from Plasma
Journal of Vascular Anomalies, 2023 Kaposiform lymphangiomatosis is a rare lymphatic anomaly that occurs in children and is associated with life-threatening complications. The somatic mutation NRAS Q61R (c.182A>G) has been identified in lesional tissue samples of patients with kaposiform ...
Fiona Lynch +2 more
doaj +1 more source
How we approach the diagnosis and management of complex lymphatic anomalies [PDF]
Pediatric Blood & Cancer, 2020 Complex lymphatic anomalies are congenital diseases of the lymphatic circulation system that are associated with significant morbidity and early mortality. While guidelines for the comprehensive evaluation of the complex lymphatic anomalies were recently published, the diagnostic approach and medical management are not standardized.
Kiersten W. Ricci, Ionela Iacobas
openaire +2 more sources