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Generalized Lymphatic Anomaly as a Differential Diagnosis of Lytic Lesions [PDF]

Case Reports in Oncology, 2023
Generalized lymphatic anomaly (GLA) is an infrequent multiorgan disease characterized by the presence of abnormal proliferation of lymphatic vessels. The diagnosis requires histological confirmation, and the treatment is controversial.
Greta Catani, Federico Waisberg, Diego Enrico, Andrés Rodriguez, Yanina Pflüger, María Laura Galluzzo, María del Valle Centeno, Isabel Colmenero, Mora Amat, Lisandro Paganini, Anna Frida García Herrmann, Matías Chacón   +11 more
doaj   +5 more sources

Primary Intestinal Lymphangiectasia and its Association With Generalized Lymphatic Anomaly

Journal of Pediatrics Review, 2016
Background: Lymph is a fluid originating in the interstitial spaces of the body that contains cells, proteins, particles, chylomicrons, and sometimes bacteria.
Victoria María Díaz Marugán, Juan Carlos Lopez-Gutierrez   +1 more
doaj   +5 more sources

Chylothorax and constrictive pericarditis in a woman due to generalized lymphatic anomaly: a case report [PDF]

Journal of Cardiothoracic Surgery, 2018
Background Generalized lymphatic anomaly (GLA) is characterized by diffuse or multicentric proliferation of dilated lymphatic vessels resembling common lymphatic malformations.
Hongchun Du, Mai Xiong, Huai Liao, Yifeng Luo, Huijuan Shi, Canmao Xie   +5 more
doaj   +4 more sources

Complex Lymphatic Anomaly Presenting with Chylothorax, Chylous Ascites, and Generalized Subcutaneous Edema in a Young Cat: Comparative Insights Based on the Human ISSVA Classification

Veterinary Sciences
In human medicine, the 2025 International Society for the Study of Vascular Anomalies (ISSVA) classification distinguishes localized lymphatic malformations from systemic disorders referred to as complex lymphatic anomalies (CLAs), including generalized ...
Kazuyuki Terai, Aki Takeuchi, Ikki Mitsui, Tomohiro Yoshida, Akari Hatanaka, Ahmed Farag, Ryou Tanaka   +6 more
doaj   +4 more sources

Generalized lymphatic anomaly involving the pleura and bone in an older male: A case report

Respiratory Medicine Case Reports, 2023
Generalized lymphatic anomaly (GLA) is a congenital malformation of the lymphatic vessels that is often diagnosed in early childhood. Owing to the rarity and heterogeneity of its clinical course, GLA is frequently misdiagnosed, especially in adults. A 67-
Atsushi Yanagisawa, Akihiro Tamiya, Takayuki Takimoto, Hiromitsu Sumikawa   +3 more
doaj   +5 more sources

Novel Discovery of ROS1:PPFIBP1 fusion protein in General Lymphatic Anomaly

Journal of Vascular Anomalies, 2023
Generalized lymphatic anomaly (GLA) is a morbid condition with few treatment options. Cure is currently not possible, and therefore, treatment is aimed at symptom relief, improving function, and slowing the progression of disease.
Angela Kadenhe-Chiweshe, Michael Baad, Shipra Kaicker, Susan Mathew, Bradley Pua, Shaun Steigman, Catherine McGuinn   +6 more
doaj   +4 more sources

Case report: Generalized lymphatic anomaly of multiple abdominal organs in a young dog

Frontiers in Veterinary Science, 2023
A 9-month-old, female Pomeranian dog presented with vomiting and lethargy. Ultrasonography revealed multilobulated anechoic round shape structures at the ovarian and uterine locations.
So-Hyeon Park, Jung-Ha Lee, Elisa N. Salas, Myeongsu Kim, Jae-ik Han, Kichang Lee, Hakyoung Yoon   +6 more
doaj   +3 more sources

Sirolimus treatment for intractable lymphatic anomalies: an open-label, single-arm, multicenter, prospective trial

Frontiers in Medicine
IntroductionIntractable lymphatic anomalies (LAs) include cystic lymphatic malformation (LM; macrocystic, microcystic, or mixed), generalized lymphatic anomaly, and Gorham–Stout disease. LAs can present with severe symptoms and poor prognosis.
Michio Ozeki, Michio Ozeki, Saori Endo, Shiho Yasue, Akifumi Nozawa, Ryuta Asada, Ryuta Asada, Akiko M. Saito, Hiroya Hashimoto, Hiroya Hashimoto, Takumi Fujimura, Yohei Yamada, Tatsuo Kuroda, Shigeru Ueno, Shoji Watanabe, Shunsuke Nosaka, Mikiko Miyasaka, Akihiro Umezawa, Kentaro Matsuoka, Takanobu Maekawa, Satoshi Hirakawa, Taizo Furukawa, Shigehisa Fumino, Tatsuro Tajiri, Tatsuro Tajiri, Junkichi Takemoto, Ryota Souzaki, Yoshiaki Kinoshita, Akihiro Fujino, Akihiro Fujino   +29 more
doaj   +3 more sources

Kaposiform Lymphangiomatosis in a Male Adolescent: A Clinical Challenge and the Role of Genetics

Journal of Investigative Medicine High Impact Case Reports, 2023
Kaposiform lymphangiomatosis (KLA) is a rare and aggressive generalized lymphatic anomaly (GLA), with distinctive clinical, radiology, morphologic, and genetic features.
Joana Pereira-Nunes MD, Miguel Madureira MD, Alexandra Dinis MD, Helena Barroca MD, Jorge Lima Msc, Maria do Bom-Sucesso MD   +5 more
doaj   +1 more source

Generalized lymphatic anomalies and review of the current management landscape: a case report and review of the literature

Journal of Medical Case Reports, 2021
Background Generalized lymphatic anomaly previously known as diffuse systemic lymphangiomatosis is a rare multisystem congenital disease arising from the lymphatic system, and it is characterized by abnormal proliferation of the lymphatic channels in ...
Tao Liu, Sana Basseri, Ben Mussari, Dominique DaBreo, Sandip SenGupta, Dalila Villalobos, Sara Awad   +6 more
doaj   +1 more source