Results 91 to 100 of about 170,403 (264)

Non-Self-Adjoint Singular Sturm-Liouville Problems with Boundary Conditions Dependent on the Eigenparameter

open access: yesAbstract and Applied Analysis, 2010
Let 𝐴 denote the operator generated in 𝐿2(ℛ+) by the Sturm-Liouville problem: −𝑦+𝑞(𝑥)𝑦=𝜆2𝑦, 𝑥∈ℛ+=[0,∞), (𝑦/𝑦)(0)=(𝛽1𝜆+𝛽0)/(𝛼1𝜆+𝛼0), where 𝑞 is a complex valued function and 𝛼0,𝛼1,𝛽0,𝛽1∈𝒞, with 𝛼0𝛽1−𝛼1𝛽0≠0.
Elgiz Bairamov, M. Seyyit Seyyidoglu
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Finite-time singularities and flow regularization in a hydromagnetic shell model at extreme magnetic Prandtl numbers

open access: yesNew Journal of Physics, 2015
Conventional surveys on the existence of singularities in fluid systems for vanishing dissipation have hitherto tried to infer some insight by searching for spatial features developing in asymptotic regimes.
G Nigro, V Carbone
doaj   +1 more source

$L^2$ -Serre Duality on Singular Complex Spaces and Rational Singularities [PDF]

open access: yesInternational Mathematics Research Notices, 2017
30 pages; completely revised version with more details on the topological ...
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

ZETA FUNCTION AND VALUE SEMIGROUP OF COMPLEX PLANE CURVE SINGULARITIES

open access: yesTạp chí Khoa học Đại học Đà Lạt
In the work by A’Campo and Oka (1996), Tschirnhausen resolution towers arose as a nice tool when studying complex irreducible plane curve singularities.
Tuan Hiep Dang   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

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