Results 71 to 80 of about 5,245,414 (245)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Quantum cores of optical phase singularities [PDF]
, 2004 The nodal line singularities (optical vortices) of classical scalar optics are smoothed in quantum optics, because of spontaneous emission into unoccupied modes. The radius of the 'quantum core' surrounding each classical singularity is proportional to ??
Dennis, MR +5 more
core +1 more source
The Complex Charge Paradigm: A New Approach for Designing Electromagnetic Wavepackets
Advanced Science, 2020 Singularities in optics famously describe a broad range of intriguing phenomena, from vortices and caustics to field divergences near point charges. The diverging fields created by point charges are conventionally seen as a mathematical peculiarity that ...
Liang Jie Wong +2 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Differential forms on free and almost free divisors [PDF]
, 2000 We introduce a variant of the usual Kähler forms on singular free divisors, and show that it enjoys the same depth properties as Kähler forms on isolated hypersurface singularities.
Mond, D. (David)
core +1 more source
Abstract and Applied Analysis, 2010 Let 𝐴 denote the operator generated in 𝐿2(ℛ+) by the Sturm-Liouville problem: −𝑦+𝑞(𝑥)𝑦=𝜆2𝑦, 𝑥∈ℛ+=[0,∞), (𝑦/𝑦)(0)=(𝛽1𝜆+𝛽0)/(𝛼1𝜆+𝛼0), where 𝑞 is a complex valued function and 𝛼0,𝛼1,𝛽0,𝛽1∈𝒞, with 𝛼0𝛽1−𝛼1𝛽0≠0.
Elgiz Bairamov, M. Seyyit Seyyidoglu
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Singularities in the flying electromagnetic doughnuts
Nanophotonics, 2019 Flying doughnuts (FDs) are exact propagating solutions of Maxwell equations in the form of single-cycle, space-time non-separable toroidal pulses. Here we review their properties and reveal the existence of a complex and robust fine topological structure.
Zdagkas Apostolos +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source