Results 81 to 90 of about 171,221 (281)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Lee–Yang edge singularities in QCD via the Dyson–Schwinger equations

European Physical Journal C: Particles and Fields
We take the Dyson–Schwinger Equation approach of QCD for the quark propagator at complex chemical potential to study the QCD phase transition. The phase transition line of the $$(2+1)$$ ( 2 + 1 ) -flavor QCD matter in the imaginary chemical potential ...
Zi-Yan Wan, Yi Lu, Fei Gao, Yu-xin Liu
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Non-Self-Adjoint Singular Sturm-Liouville Problems with Boundary Conditions Dependent on the Eigenparameter

Abstract and Applied Analysis, 2010
Let 𝐴 denote the operator generated in 𝐿2(ℛ+) by the Sturm-Liouville problem: −𝑦+𝑞(𝑥)𝑦=𝜆2𝑦, 𝑥∈ℛ+=[0,∞), (𝑦/𝑦)(0)=(𝛽1𝜆+𝛽0)/(𝛼1𝜆+𝛼0), where 𝑞 is a complex valued function and 𝛼0,𝛼1,𝛽0,𝛽1∈𝒞, with 𝛼0𝛽1−𝛼1𝛽0≠0.
Elgiz Bairamov, M. Seyyit Seyyidoglu
doaj   +1 more source

The Complex Charge Paradigm: A New Approach for Designing Electromagnetic Wavepackets

Advanced Science, 2020
Singularities in optics famously describe a broad range of intriguing phenomena, from vortices and caustics to field divergences near point charges. The diverging fields created by point charges are conventionally seen as a mathematical peculiarity that ...
Liang Jie Wong, Demetrios N. Christodoulides, Ido Kaminer   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Links of complex analytic singularities [PDF]

Surveys in Differential Geometry, 2012
This is a part survey part research paper studying the local topology of complex analytic spaces. We review and strengthen the results of Kapovich--Koll r "Fundamental groups of links of isolated singularities" (1109.4047) and incorporate the paper "Dual graphs of exceptional divisors" (1203.2640) into the current one.
openaire   +3 more sources

Singularities in the flying electromagnetic doughnuts

Nanophotonics, 2019
Flying doughnuts (FDs) are exact propagating solutions of Maxwell equations in the form of single-cycle, space-time non-separable toroidal pulses. Here we review their properties and reveal the existence of a complex and robust fine topological structure.
Zdagkas Apostolos, Papasimakis Nikitas, Savinov Vassili, Dennis Mark R., Zheludev Nikolay I.   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source