Results 81 to 90 of about 5,245,414 (245)

The numerical solution of elliptic and parabolic partial differential equations with boundary singularities [PDF]

open access: yes, 1976
A general numerical method is described for the solution of linear elliptic and parabolic partial differential equations in the presence of boundary singularities.
Furzeland, RM, Crank, J
core   +3 more sources

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Finite-time singularities and flow regularization in a hydromagnetic shell model at extreme magnetic Prandtl numbers

open access: yesNew Journal of Physics, 2015
Conventional surveys on the existence of singularities in fluid systems for vanishing dissipation have hitherto tried to infer some insight by searching for spatial features developing in asymptotic regimes.
G Nigro, V Carbone
doaj   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

ZETA FUNCTION AND VALUE SEMIGROUP OF COMPLEX PLANE CURVE SINGULARITIES

open access: yesTạp chí Khoa học Đại học Đà Lạt
In the work by A’Campo and Oka (1996), Tschirnhausen resolution towers arose as a nice tool when studying complex irreducible plane curve singularities.
Tuan Hiep Dang   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Subregular representations of Sln and simple singularities of type An-1. Part II [PDF]

open access: yes, 2003
The aim of this paper is to show that the structures on K-theory used to formulate Lusztig's conjecture for subregular nilpotent sln-representations are, in fact, natural in the McKay correspondence.
Rumynin, D.   +5 more
core   +1 more source

Bouncing singularities and thermal correlators on line defects

open access: yesJournal of High Energy Physics
Thermal correlators in holographic conformal field theories are known to exhibit singularities in complex time, sometimes referred to as “bouncing singularities”, which are believed to be related to bulk geodesics probing the black hole interior.
Simone Giombi, Yue-Zhou Li, Jieru Shan
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

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