Results 101 to 110 of about 171,221 (281)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Complex Singularity and Unitarity [PDF]

Progress of Theoretical Physics, 1965
Mishima, N., Yamazaki, M.
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A C 2,α,β estimate for complex Monge–Ampère type equations with conic sigularities

Advanced Nonlinear Studies
In this paper, we give an alternative approach to the C 2,α,β estimate for complex Monge-Ampère equations with cone singularities along simple normal crossing divisors.
Huang Liding, Tian Gang, Wang Jiaxiang
doaj   +1 more source

Principal Functions of Nonselfadjoint Discrete Dirac Equations with Spectral Parameter in Boundary Conditions

Abstract and Applied Analysis, 2012
Let denote the operator generated in by , , , and the boundary condition , where , , , and , are complex sequences, , , and is an eigenparameter. In this paper we investigated the principal functions corresponding to the eigenvalues and the spectral ...
Yelda Aygar, Murat Olgun, Turhan Koprubasi   +2 more
doaj   +1 more source

Non-geometric vacua of the Spin(32)/ℤ 2 heterotic string and little string theories

Journal of High Energy Physics, 2017
We study a class of 6d N $$ \mathcal{N} $$ = (1, 0) non-geometric vacua of the Spin(32)/ℤ 2 heterotic string which can be understood as fibrations of genus-two curves over a complex one-dimensional base.
Anamaría Font, Christoph Mayrhofer
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Study of Movable Singularities in Non-Algebraic First-Order Autonomous Ordinary Differential Equations

Mathematics
We studied the movable singularities of solutions of autonomous non-algebraic first-order ordinary differential equations in the form of y′=I(y(t)) and y′=I1(y(t))+I2(y(t))+⋯+In(y(t)), aiming to prove that all movable singularities of all complex ...
Xingyu Liu
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source