Results 61 to 70 of about 5,837 (259)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
ON THE TOPOLOGY OF A RESOLUTION OF ISOLATED SINGULARITIES, II
, 2020 Let Y be a complex projective variety of dimension n with isolated singularities, π: X → Y a resolution of singularities, G:= π−1 (Sing(Y)) the exceptional locus.
Di Gennaro V +3 more
core +1 more source
Complex Riemannian Spacetime and Singularity-Free Black Holes and Cosmology
AxiomsAn approach is presented to address singularities in general relativity using a complex Riemannian spacetime extension. We demonstrate how this method can be applied to both black hole and cosmological singularities, specifically focusing on the ...
John W. Moffat
doaj +1 more source
Non compact boundaries of complex analytic varieties in Hilbert spaces
Complex Manifolds, 2014 We treat the boundary problem for complex varieties with isolated singularities, of complex dimension greater than or equal to 3, non necessarily compact, which are contained in strongly convex, open subsets of a complex Hilbert space H.We deal with the ...
Mongodi Samuele, Saracco Alberto
doaj +1 more source
Electronic Journal of Qualitative Theory of Differential Equations, 2015 In this article we prove a classification theorem (Main theorem) of real planar cubic vector fields which possess two distinct infinite singularities (real or complex) and eight invariant straight lines, including the line at infinity and including ...
Cristina Bujac, Nicolae Vulpe
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
An Introduction to Lipschitz Geometry of Complex Singularities [PDF]
, 2020 50 pages, 36 ...
openaire +2 more sources
Complex Singularity Analysis for a Nonlinear PDE [PDF]
Communications in Partial Differential Equations, 2006 We introduce a method of rigorous analysis of the location and type of complex singularities for nonlinear higher order PDEs as a function of the initial data. The method is applied to determine rigorously the asymptotic structure of singularities of the modified Harry-Dym equation $$ H_t + H_y = - {1/2} H^3 + H^3 H_{yyy} : H(y, 0) = y^{-1/2} $$ for ...
Costin, O., Tanveer, S.
openaire +2 more sources