Results 41 to 50 of about 3,659,226 (218)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Stokes diagnostics of simulated solar magneto-convection [PDF]

, 2007
We present results of synthetic spectro-polarimetric diagnostics of radiative MHD simulations of solar surface convection with magnetic fields. Stokes profiles of Zeeman-sensitive lines of neutral iron in the visible and infrared spectral ranges emerging
Shelyag, S., S. K. Solanki, Vögler, Alexander, Solanki, S., Schüssler, M., M. Schüssler, Shelyag, Sergiy, Solanki, Sami K., Schüssler, Manfred, A. Vögler, Vögler, A., S. Shelyag   +11 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Laboratory Markers Used for the Diagnoses of Food, Respiratory, Skin, and Drug Allergies

مجلة كلية الطب
Background: Allergies, as prevalent conditions, significantly impact individuals' health and quality of life. The criticality of accurate diagnosis cannot be overstated, as it is the cornerstone for effective management and treatment, underscoring the ...
Abdalla E. Ali, Baraa A. Eltoum, Alneil M. Hamza   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

CURRENT CHALLENGES, RECENT ACHIEVEMENTS, AND FUTURE DIRECTIONS FOR THE DEVELOPMENT OF IMMUNOLOGY, ALLERGOLOGY, AND RHEUMATOLOGY

Proceedings of the Shevchenko Scientific Society: Medical Sciences
Clinical immunology, allergology, and rheumatology play a vital role in modern medicine, combining fundamental scientific research with practical healthcare.
Svitlana Zubchenko, Marta Lomikovska, Serhii Yuriev   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluating clinical importance of sensitization to Ara h 6 quantitively in Japanese children

World Allergy Organization Journal
Background: The clinical importance of sensitization to Arachis hypogaea 6 (Ara h 6) in Japanese children remains unelucidated. We aimed to quantitatively evaluate the clinical importance of sensitization to Ara h 6 in managing peanut allergy in Japanese
Sakura Sato, MD, Noriyuki Yanagida, MD, PhD, Ken-ichi Nagakura, MD, PhD, Kyohei Takahashi, MD, PhD, MPH, Magnus P. Borres, MD, PhD, Motohiro Ebisawa, MD, PhD   +5 more
doaj   +1 more source