Results 61 to 70 of about 3,659,226 (218)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Pediatric anaphylaxis: age-related symptom trends and the limited role of allergen molecules: a retrospective analysis

Allergy, Asthma & Clinical Immunology
Background Emerging evidence suggests that specific allergen molecules may influence the clinical phenotype of anaphylaxis in children, but robust data are scarce.
Izabela Kucharek, Krzysztof Przystał-Dyszyński, Aleksandra Godyńska, Maria Gregorczyk, Natasza Krajewska, Adam J. Sybilski   +5 more
doaj   +1 more source

Concordance between crude extract and component allergens in a multiple allergen simultaneous test: a large-scale retrospective analysis

British Journal of Biomedical Science
ObjectivesMultiple allergen simultaneous tests (MAST) increasingly incorporate both crude extract and molecular component allergens for specific IgE testing.
Hyejin Ryu, Kuenyoul Park, Kina Kim, Dohsik Minn   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

THE ROLE OF COMPONENT-BASED DIAGNOSTICS IN HAZELNUT ALLERGY TESTING

Health Problems of Civilization, 2023
Adrienn Szalai, Eva Dojcsakne Kiss-Tóth, Bertalan Fodor   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Clinical and immunological markers of peanut allergy severity and tolerance in children

Frontiers in Allergy
BackgroundImproved diagnostic tools are needed to assess the risk of severe peanut allergy (PA) and/or predict its resolution.MethodsThis prospective multicenter cross-sectional study with follow-up elements (2020–2024) included children aged 3 months–18 
Tadej Petek, Brigita Koren, Maja Tomazin, Tina Hojnik, Vojko Berce, Mija Lajhar, Blažka Krašovec, Matjaž Homšak, Maja Skerbinjek Kavalar, Peter Korošec, Peter Korošec   +10 more
doaj   +1 more source

Diagnostic approaches for differentiating between true fruit allergy and oral allergy syndrome [PDF]

International Journal of Minor Fruits, Medicinal and Aromatic Plants
The purpose of the present study was to identify diagnostic markers that would allow distinguishing true food allergy to fruits from oral allergy syndrome, as well as to evaluate the efficacy of various diagnostic approaches. The study included 182 adult
Maria Zofia Lisiecka
doaj   +1 more source