Results 111 to 120 of about 995,298 (311)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Separation of concerns in hybrid agent and component system

, 2010
Modularising requirements is a classic problem of software engineering; concerns often overlap, requiring multiple dimensions of decomposition to achieve separation.
Collier, Rem W., Jordan, Howell R., Rem W. Collier (12618934), Dragone, Mauro; id_orcid, Mauro Dragone (12618925), David Lillis (12618931), Jordan, Howell, Howell Jordan, Howell Jordan (12618928), Collier, Rem, Rem W. Collier, Mauro Dragone, Lillis, David, David Lillis, Dragone, Mauro   +14 more
core   +1 more source

Empirical Validation of Component-based Software Systems Generation and Evaluation Approaches

CLEI Electronic Journal, 2010
Component-based software development needs to formalize a process of generation, evaluation and selection of Composite COTS-based Software Systems (CCSS), enabling software architects to make early decisions; the Azimut approach and its associated ...
Víctor Sagredo, Carlos Becerra, Gonzalo Valdes   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Component-based model-driven software development.

, 2011
Model-driven software development (MDSD) and component-based software development are both paradigms for reducing complexity and for increasing abstraction and reuse in software development. In this thesis, we aim at combining the advantages of each by introducing methods from component-based development into MDSD.
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

COSFoTS: component oriented software framework for telecommunication software

Tongxin xuebao, 2007
Based on the research of software framework and analysis on telecommunication software,component ori-ented software framework for telecommunication software（COSFoTS） was put forwared.The architecture and the key issues of COSFoTS,such as software bus ...
HUANG Xing-ping, LONG Xiang-ming, XU Peng, YANG Fang-chun   +3 more
doaj   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Pluig 'n Train - A Component Based Approach [PDF]

Interaction Design and Architecture(s), 2010
Technology enhanced learning can look back on a comparably long tradition. Surprisingly, the software systems in this field are seldom constructed based on state-of-the art insights in software engineering.
Alke Martens, Dennis Maciuszek, Géraldine Ruddeck, Martina Weicht   +3 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source