Results 91 to 100 of about 995,298 (311)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Research Article Software Component Selection Based on Quality Criteria Using the Analytic Network Process

, 2014
Component based software development (CBSD) endeavors to deliver cost-effective and quality software systems through the selection and integration of commercially available software components.
Nazir, Shah, Ali, Muhammad, Shahzad, Sara, Amin, Rohul, Cosmas, John, Lazaridis, Pavlos, Anwar, Sajid, Sher Afzal, Khan, Nawaz, Muhammad   +8 more
core  

Built-in contract testing in component-based application engineering

, 2022
S.87-100 : Ill., Lit.Assembling new software systems from prefabricated components is an attractive alternative to traditional software engineering practices and promises to increase reuse and reduce development costs.
Groß, H.-G.
core  

Semantic model-driven architecting of service-based software systems [PDF]

, 2007
Model-driven development is a software development framework that emphasises model-based abstraction and automated code generation. Service-based software architectures benefit in particular from semantic, ontology-based modelling.
Claus Pahl, Pahl, Claus
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Principles of UML-based component modeling

, 2022
S.70-85 : Ill., Lit.With the proliferation of middleware technologies and component infrastructures, there is a growing need to support high-level, platform.independent ways of modeling components and component-based systems.
Bunse, C., Kamsties, E., Zettel, J., Atkinson, C.   +3 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Design Patterns and Component Framework for Building RTSJ-Based Real-Time Middleware [PDF]

, 2010
The middleware is a software layer located on top of the operating system that uses its facilities, integrates with it, and extends its functionality in order to support the development of effective and reliable distributed systems; however, the ...
Alrahmawy, Mohammed
core  

Distributed component technologies and their software engineering implications

, 2002
In this state of the art report, we review advances in distributed component technologies, such as the Enterprise Java Beans specification and the CORBA Component Model. We assess the state of industrial practice in the use of distributed components.
Wolfgang Emmerich, Emmerich, W
core   +1 more source

A Component-Oriented Programming for Embedded Mobile Robot Software

International Journal of Advanced Robotic Systems, 2007
Applying software reuse to many Embedded Real-Time (ERT) systems poses significant challenges to industrial software processes due to the resource-constrained and real-time requirements of the systems.
Dayang N. A. Jawawi, Rosbi Mamat, Safaai Deris   +2 more
doaj   +1 more source