Results 111 to 120 of about 549,019 (312)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Effect of Moisture on the Material Properties of Composite Material
Nowadays, composite materials are widely used in the aeronautical industry to manufacture many different components. Development of composite materials has a very positive influence on the performance, reliability, weight and cost of modern aircraft. But
Kovaļovs, Andrejs +2 more
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Preparation and Applications of Polyamide 6/ IRM? Tooth Root Composite Filling Material
, 2012 [[abstract]]Intermediate restorative material (IRM®) is the most commonly used temporary filling material. This research mixed IRM with Polyamide 6 (Nylon 6) fibers, forming the Nylon/IRM tooth root composite filling materials. Tests such as setting time,
Chao Tsang Lu;Jia Horng Lin;Ching Wen Lin;Wen Cheng Chen;Po Ching Lu;Ching Wen Lou
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Fluorinated Polymers for Photonics—From Optical Waveguides to Polymer-Clad Glass Optical Fibers
Applied SciencesIn this paper, our work in the field of fluorinated UV-curable polymers is reviewed. These polymers possessing tunable low refractive indices and low optical propagation losses for telecommunication wavelengths are intended to be used as core and ...
Leonid M. Goldenberg +2 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Multiscale Approach for the Design of Composite Sandwich Elements
, 2010 In the present work, composite sandwich components, that perfectly match the challenging demands of lightweight and more customized structures, have been characterized and designed as a roof panels of a railway vehicle.
Zinno, Alberto
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Behaviour of semi-rigid composite connections for steel framed buildings [PDF]
, 2009 During propped construction the steel-concrete composite action resists dead as well as imposed loads. Conversely, the steel section alone resists the floor self-weight in unpropped beams.
Muniasamy, D.
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Advanced Materials for Composite Armour
, 2009 PhDComposite integral armour plays an important role in future combat system. Despite numerous experimental studies there are still disadvantages such as complex manufacturing process, relatively big damage area, difficult to repair and limit shape etc.
Zhu, Fuyou
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