Results 121 to 130 of about 6,887,631 (298)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Effect of Temperature on Corrosion Behavior of X65 Steel in Simulated Deep Sea Environment
International Journal of Electrochemical Science, 2019 Liqin Wang +5 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Silkfibroin-Ca-P composite bone replacement material for guided bone growth
, 2015 Mineralized natural protein based materials are investigated as novel materials to be used in tissue engineering and as bone replacement materials.
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Shock and VibrationA method to deduce the characteristics of rail corrugation was developed and presented in this paper. It has been found that noise and vibration in the train vehicle were primarily contributed by rail corrugation and wheel polygonalisation.
Xiaohan Phrain Gu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Investigation of the possibility to regulate the boundary processes in the composite material made from scrap tires and polymer binder must be considered as a perspective direction so that to regulate the essential properties of composite material.
Mālers, Laimonis, Plēsuma, Renāte
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Advanced Materials for Composite Armour [PDF]
, 2009 PhDComposite integral armour plays an important role in future combat system. Despite numerous experimental studies there are still disadvantages such as complex manufacturing process, relatively big damage area, difficult to repair and limit shape etc.
Zhu, Fuyou
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