Results 131 to 140 of about 552,574 (312)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

A structural design comparison of metallic and composite aircraft pressure retaining doors [PDF]

open access: yes, 2012
The pressure retaining door is obviously a sensible part of an aircraft, and the design criteria is much more critical than for the fuselage, so a problem caused by this critical criteria is the heavy weight of the door structure because it should be ...
Liu, Hongfen
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Effect of current density on the microstructure and properties of supercritical Ni-FG composite electrodeposited layers

open access: yesJournal of Materials Research and Technology
This study investigates the surface morphology and microstructure of nickel (Ni) plating and nickel-fluorinated graphene (Ni-FG) composite plating, both produced using a direct current (DC) power supply under standard and supercritical conditions.
Haoyu Zhong   +4 more
doaj   +1 more source

Structural integrity of engineering components made of functionally graded materials [PDF]

open access: yes, 2008
Functionally graded materials (FGM) are composite materials with microstructure gradation optimized for the functioning of engineering components. For the case of fibrous composites, the fibre density is varied spatially, leading to variable material ...
Oyekoya, Oyedele O.
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

The Influence of Composition and Technology on the Properties of Composite Material Based on Scrap Tires and Polymer Binder [PDF]

open access: yes
The presented work is dedicated to the examination of effect of hardening temperature and composition on the mechanical properties of composite material made from mechanically grinded scrap tires and polyurethane type binder with different reactivity ...
Mālers, Laimonis   +2 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Effect of Temperature on Corrosion Behavior of X65 Steel in Simulated Deep Sea Environment

open access: yesInternational Journal of Electrochemical Science, 2019
Liqin Wang   +5 more
doaj   +1 more source

Correlation between Composition and Properties of Composite Material Based on Scrap Tires [PDF]

open access: yes
Purpose of present work is to investigate mechanical and insulation properties of the composite material based on scrap tires and polyurethane-type binder in correlation with composition of composite material. The studies of material’s hardness must be
Mālers, Laimonis   +3 more
core  

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