Results 141 to 150 of about 10,377,272 (361)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

High Modulus Carbon Fiber and the Relating Composite Material

, 1968
Yoshiaki SAKATANI, Shigehiko Yamada
openalex   +2 more sources

Advanced composite material simulation

, 2008
A computational methodology is presented for modeling the non-linear mechanical behavior of composite structures made of FRP (Fiber-Reinforced Polymers) laminates. The model is based on the appropriate combination of the constitutive models of compounding materials, considered to behave as isolated continua, together with additional “closure equations”
Oller Martínez, Sergio Horacio, Martínez, X, Barbat Barbat, Horia Alejandro, Rastellini, F   +3 more
openaire   +4 more sources

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

On the Occasion of Issuance of Special Issue on the Mechanical Characteristics of Composite Materials

, 1968
Takeshi KUNIO, Katsunobu TOMITA
openalex   +2 more sources

Damping Measurements of a Controlled Composite Material [PDF]

, 1974
Eleanor Jones, R. L. Sierakowski, C. A. Ross   +2 more
openalex   +1 more source

Fracture of Composite Materials [PDF]

Journal of Applied Mechanics, 1980
C. W. Smith, G.C. Sih, V. P. Tamuzs
openaire   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

1. On the Fiber Composite Alloys : Composite Material of Metallic Series

, 1968
Ishi Miura, Hitoshi Hamanaka, Susumu Hirano   +2 more
openalex   +2 more sources

Acoustic Absorption in Some Composite Materials [PDF]

, 1970
R. W. Higgs, L. J. Eriksson
openalex   +1 more source