Results 101 to 110 of about 18,459,682 (262)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Composite Materials Engineering Graduating Class Photograph: 2020

, 2020
This is a class photograph of the Composite Materials Engineering Graduating Class of 2020 at Winona State University. The students in the photograph are: Makaylan Benz, Braxton Bliese, Kevin Eischens, Alexander Evans, Oussama Ezzaher, Nicholas Henderson,
Composite Materials Engineering Department-Winona State University
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Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Composite Materials Engineering Graduating Class Photograph: 2017

, 2017
This is a class photograph of the Composite Materials Engineering Graduating Class of 2017 at Winona State University. The students in the photograph are: Bassem Almutairi, Nezihe Alibaba, Brendon Arnold, Ryan Baillif, Kyle Bauman, Ryan Elbalawy, Brett ...
Composite Materials Engineering Department-Winona State University
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ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Composite Materials Engineering Graduating Class Photograph: 2012

, 2012
This is a class photograph of the Composite Materials Engineering Graduating Class of 2012 at Winona State University. The students in the photograph are: Richard Anfinsen, Austin Erdenberger, Ryan Foley, Ben Gerjets, Emily Hammel, Benjamin Malcheski ...
Composite Materials Engineering Department-Winona State University
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Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Composite Materials Engineering Graduating Class Photograph: 2011

, 2011
This is a class photograph of the Composite Materials Engineering Graduating Class of 2011 at Winona State University. The students in the photograph are: Eric A.
Composite Materials Engineering Department-Winona State University
core  

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source