Results 111 to 120 of about 18,459,682 (262)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Composite Materials Engineering Graduating Class Photograph: 1993

, 1993
This is a class photograph of the Composite Materials Engineering Graduating Class of 1993 at Winona State University. The students in the photograph are: Steven Beck, Shawn Boettcher, Todd Boettcher, Eric Burnham, David Hagstrom, Darin Jensen, Scott ...
Composite Materials Engineering Department-Winona State University
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Composite Materials Engineering Graduating Class Photograph: 2009

, 2009
This is a class photograph of the Composite Materials Engineering Graduating Class of 2009 at Winona State University. The students in the photograph are: Eric Boehm, Daniel Boyum, Douglas Heimer, Andrew Kes, Steven Klankowski, Bradley Lawrence, Thomas ...
Composite Materials Engineering Department-Winona State University
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Composite Materials Engineering Graduating Class Photograph: 2023

, 2023
This is a class photograph of the Composite Materials Engineering Graduating Class of 2023 at Winona State University. The students in the photograph are [alphabetical order]: Bailey Banaszynski, Jared Boelter, Daniel Dahl, Justin Dailey, Chariie Dennis,
Composite Materials Engineering-Winona State University
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Avoiding patient harm through the application of prescribing safety indicators in English general practices: the PRoTeCT research programme evaluating OptimiseRx and PINCER

Programme Grants for Applied Research
Background Hazardous prescribing is an important and expensive preventable cause of patient harm, which can be identified using electronic healthcare records.
Anthony J Avery, Rachel A Elliott, Thomas Allen, Darren M Ashcroft, Mindy Bassi, Jillian Beggs, Brian Bell, Elizabeth Camacho, Antony Chuter, Bruce Guthrie, Mark Jeffries, Richard N Keers, Pearl LH Mok, Daniel Morales, Niels Peek, Leonie Penner, Stephen A Roberts, Sarah Rodgers, Gabriel Rogers, Nde-eshimuni Salema, Azwa Shamsuddin, Aziz Sheikh, Tjeerd van Staa, Justin Waring, Amelia Taylor   +24 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source