Results 81 to 90 of about 359,557 (359)

Actin-binding compounds, previously discovered by FRET-based high-throughput screening, differentially affect skeletal and cardiac muscle [PDF]

, 2020
Piyali Guhathakurta, Lien A. Phung, Ewa Próchniewicz, Sarah Lichtenberger, Anna Wilson, David D. Thomas   +5 more
openalex   +1 more source

In Silico Screening and Molecular Dynamics Simulation Studies in the Identification of Natural Compound Inhibitors Targeting the Human Norovirus RdRp Protein to Fight Gastroenteritis [PDF]

, 2023
Rami J. Obaid, Alaa Shafie, M. Shaheer Malik, Munirah M. Al‐Rooqi, Ziad Moussa, Osama Abdulaziz, Abdulelah Aljuaid, Mamdouh Allahyani, Mazen Almehmadi, Farah Anjum, Saleh A. Ahmed   +10 more
openalex   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The emerging roles of miRNA-mediated autophagy in ovarian cancer

Cell Death and Disease
Ovarian cancer is one of the common tumors of the female reproductive organs. It has a high mortality rate, is highly heterogeneous, and early detection and primary prevention are very complex.
Yamin Ding, Xuan Huang, Tuo Ji, Cong Qi, Xuzhu Gao, Rongbin Wei   +5 more
doaj   +1 more source

Rapid and Specific Detection of Listeria monocytogenes With an Isothermal Amplification and Lateral Flow Strip Combined Method That Eliminates False-Positive Signals From Primer–Dimers

Frontiers in Microbiology, 2020
Listeria monocytogenes is an important foodborne pathogenic bacterium that is explicitly threatening public health and food safety. Rapid, simple, and sensitive detection methods for this pathogen are of urgent need for the increasing on-site testing ...
Lei Wang, Panpan Zhao, Xinxin Si, Juan Li, Xiaofang Dai, Kunxiao Zhang, Song Gao, Jingquan Dong   +7 more
doaj   +1 more source

VSFlow: an open-source ligand-based virtual screening tool

, 2022
Ligand-based virtual screening is a widespread method in modern drug design. It allows for a rapid screening of large compound databases in order to identify similar structures.
Paul, Czodrowski, Helge, Vatheuer, Sascha, Jung   +2 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Nature Bank and the Queensland Compound Library: Unique International Resources at the Eskitis Institute for Drug Discovery

, 2014
The Eskitis Institute for Drug Discovery is home to two unique resources, Nature Bank and the Queensland Compound Library (QCL), that differentiate it from many other academic institutes pursuing chemical biology or early phase drug discovery.
Quinn, Ronald, Pham, Ngoc B, Camp, David, Pham, Ngoc, Newman, Stuart, Quinn, Ronald J   +5 more
core   +1 more source

Plate layout for compound screening in MEF cells and CNS.4U cells.

, 2022
MEF and CNS.4U cells were screening using 4 chemical compounds in dose response and kinetic. Compound names: Compound 1, Compound 2, Compound 3, Compound 4. Negative control: DMSO. Positive control: Paclitaxel at 5 μM.
Jean-Philippe Stephan (40079), Eva Vermersch (12963357), Jeremy Grignard (12963351), Philippe Delagrange (588093), Véronique Lamamy (12963354), Thierry Dorval (280478), François Fages (793640)   +6 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source