Results 91 to 100 of about 359,557 (359)

Scoring functions and enrichment : a case study on Hsp90

, 2007
This work was funded by the EPSRC, InsightFaraday (now part of the Chemistry Innovation Knowledge Transfer Network), Arrow Therapeutics Ltd and Unilever plc.Background: The need for fast and accurate scoring functions has been driven by the increased use
Chrysi Konstantinou-Kirtay, Lumley James A, Konstantinou-Kirtay, Chrysi, John BO Mitchell, James A Lumley, Lumley, James A., Mitchell John BO, Mitchell, John Blayney Owen, Konstantinou-Kirtay Chrysi   +8 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Angelicin attenuates sepsis-associated acute liver injury via p38 MAPK inhibition and NF-κB-mediated Nrf2/Keap1 activation to suppress inflammation and oxidative stress

Acta Biochimica et Biophysica Sinica
Sepsis-associated acute liver injury (SALI) is a frequent and clinically severe complication of sepsis, in which inflammatory responses and oxidative stress are involved. Angelicin (ANG), one of the main active
Pan Enzhuang, Sun Huilin, Zhang Shasha, Wang Jun, Liu Yedan, Wang Feibiao, Xia Jing, Qian Yingjia, Xu Xiaolong, Dong Jingquan   +9 more
doaj   +1 more source

Development and application of fast fuzzy pharmacophore-based virtual screening methods for scaffold hopping

, 2006
The goal of this thesis was the development, evaluation and application of novel virtual screening approaches for the rational compilation of high quality pharmacological screening libraries. The criteria for a high quality were a high probability of the
Renner, Steffen
core  

Automated nano-electrospray mass spectrometry for protein-ligand screening by noncovalent interaction applied to human H-FABP and A-FABP

, 2003
A method for ligand screening by automated nano-electrospray ionization mass spectrometry (nano-ESI/MS) is described. The core of the system consisted of a chip-based platform for automated sample delivery from a 96-well plate and subsequent analysis ...
Edlund, Per Olof,, Sterling, A.,, Edlund, P-O, Åkerud, Tomas, van Pelt, C K, Roeraade, Johan,, Åkerud, T.,, Åkerud, Tomas,, Sterling, A, Van Pelt, C. K.,, Roeraade, J, Benkestock, K, Lund University., Benkestock, Kurt,   +13 more
core   +1 more source

High-throughput screening of room temperature active Peltier cooling materials in Heusler compounds [PDF]

, 2022
Huifang Luo, Xin Li, Yuxiang Wang, Yeqing Jin, Mingjia Yao, Jiong Yang   +5 more
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

High throughput screening compound validation.

, 2013
The HeLa (FXN-EGFP) stable cell line was exposed to various concentrations of compounds identified by high throughput screening. Cultures were incubated for 72 hours. The levels of EGFP expression were measured by flow cytometry.
Lucille Voullaire (283955), Martin B. Delatycki (214513), Lingli Li (61106), Chiranjeevi Sandi (283956), Mark A. Pook (126056), Panos A. Ioannou (214510), Joseph P. Sarsero (214516)   +6 more
core   +1 more source

Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites

, 2022
The identification of starting points for compound development is one of the key steps in early-stage drug discovery. Information-rich techniques such as crystallographic fragment screening can potentially increase the efficiency of this step by ...
Gustavo M. A. Lima, Markus C. Wahl, Weiss, Manfred S.,, Tatjana Barthel, Wahl, Markus C.,, Weiss, Manfred S., Lima, Gustavo M.A., Jan Wollenhaupt, Barthel, Tatjana,, Barthel, T., Wahl, Markus C., Wahl, M.C., Lima, G.M.A., Weiss, M.S., Wollenhaupt, Jan, Wollenhaupt, J., Manfred S. Weiss, Lima, Gustavo M.A.,, Lund University., Barthel, Tatjana, Wollenhaupt, Jan,   +20 more
core   +1 more source