Results 111 to 120 of about 328,812 (261)

Rapid and sensitive detection of Oncorhynchus mykiss adulteration in Salmo salar by recombinase polymerase amplification combined with lateral flow strip

Acta Biochimica et Biophysica Sinica, 2022
Yang Qiankun, Liu Xia, Wang Lei, Yu Guili, Yang Haitao, Fu Hang, Li Xueqing, He Nana, Yu Hong, Dong Jingquan   +9 more
doaj   +1 more source

Automated in vivo compound screening with zebrafish and the discovery and validation of PD 81,723 as a novel angiogenesis inhibitor. [PDF]

Sci Rep, 2022
Mauro AN, Turgeon PJ, Gupta S, Brand-Arzamendi K, Chen H, Malone JH, Ng R, Ho K, Dubinsky M, Di Ciano-Oliveira C, Spring C, Plant P, Leong-Poi H, Marshall JC, Marsden PA, Connelly KA, Singh KK.   +16 more
europepmc   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A context-aware deconfounding autoencoder for robust prediction of personalized clinical drug response from cell-line compound screening. [PDF]

Nat Mach Intell, 2022
He D, Liu Q, Wu Y, Xie L.
europepmc   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. [PDF]

Front Mol Biosci, 2022
Mrozek A, Antoshchenko T, Chen Y, Zepeda-Velázquez C, Smil D, Kumar N, Lu H, Park HW.   +7 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Phytochemical Compound Screening to Identify Novel Small Molecules against Dengue Virus: A Docking and Dynamics Study. [PDF]

Molecules, 2022
Shimu MSS, Mahmud S, Tallei TE, Sami SA, Adam AA, Acharjee UK, Paul GK, Emran TB, Zaman S, Uddin MS, Saleh MA, Alshehri S, Ghoneim MM, Alruwali M, Obaidullah AJ, Jui NR, Kim J, Kim B.   +17 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability. [PDF]

Nat Cell Biol
D'Ambrosio M, White MEH, Gavriil ES, Bousset L, Birch J, Gruevska A, Pasquini E, Colucci M, Fong W, Mosole S, Valdata A, Veroutis D, Tyson K, Ranvir V, Prokosch S, Pombo J, Ardisson A, Khadayate S, Young G, Montoya A, Roumelioti G, Houghton J, Lu J, Shliaha PV, De Vita E, Vernia S, Gorgoulis VG, Gallage S, Heikenwälder M, Hall Z, Alimonti A, McNeish IA, Tate EW, Gil J.   +33 more
europepmc   +1 more source