Results 101 to 110 of about 359,557 (359)

Tapping the Unexplored Potential of Marine Fungi and Edible Mushrooms for in Silico Screening of Anti-Viral Bioactive Compounds Against SARS-CoV-2 for Rapid Development of Nutraceuticals [PDF]

, 2020
Amit Kumar Srivastav, Jyoti Jaiswal, Umesh Kumar   +2 more
openalex   +1 more source

Screening of Chorioamnionitis Using Volatile Organic Compound Detection in Exhaled Breath: A Pre-clinical Proof of Concept Study [PDF]

, 2021
Daan R. M. G. Ophelders, Agnes W. Boots, Matthias C. Hütten, Salwan Al‐Nasiry, Reint K. Jellema, O. Brad Spiller, Frederik‐Jan van Schooten, Agnieszka Smolinska, Tim G. A. M. Wolfs   +8 more
openalex   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Mannose-B from Codonopsis pilosula modulates LAMB1 expression to enhance trophoblast function and alleviate subchorionic hematoma

Scientific Reports
This study investigates the active component Mannose-B from Codonopsis pilosula and its effect on human trophoblast cell function, particularly focusing on the regulation of Laminin Subunit Beta 1 (LAMB1) expression and its implications in subchorionic ...
Qian Sun, Yuan Gao, Kadirya Asan, Jing Ji, Jinjin Xu, Xiaoyan Wu, Jie Ren, Wen Feng, Mengwei Song, Sen Wang, Boyu Zhang, Ying Zhou, Conghui Han, Shun Liu, Wen Yang   +14 more
doaj   +1 more source

Rescuing compound bioactivity in a secondary cell-based screening by using γ-cyclodextrin as a molecular carrier

, 2015
Rafael Claveria-Gimeno,1–3 Sonia Vega,3 Valeria Grazu,4 Jesús M de la Fuente,4–6 Angel Lanas,2,8–10 Adrian Velazquez-Campoy,2,3,7 Olga Abian1–3,8 1Instituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain ...
Claveria-Gimeno R, Abian O, Grazu V, de la Fuente JM, Lanas A, Vega S, Velazquez-Campoy A   +6 more
core  

Preliminary Screening of Active Compounds with Evaluation the Anti-Pseudomonas Aeruginosa Bacteria Activity of Ashwagandha (Withania Somnifera) Leaves Extracted by Different Types Solvents

, 2023
Ali Rasool Mahmood Albakaa, Q. A. Abeer, Nehad K. Abed   +2 more
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Assessing biologic/toxicologic effects of extractables from plastic contact materials for advanced therapy manufacturing using cell painting assay and cytotoxicity screening

Scientific Reports
Plastic components are essential in the pharmaceutical industry, encompassing container closure systems, laboratory handling equipment, and single-use systems.
Ina Pahl, Axel Pahl, Armin Hauk, Dana Budde, Sonja Sievers, Lothar Fruth, Roberto Menzel   +6 more
doaj   +1 more source

Enhancing Multifunctional Drug Screening via Artificial Intelligence

Computational drug screening is of fundamental importance in early-stage drug discovery. The current computational methods predict compound affinities to their targets based on docking or pharmacophore (PH4) hypotheses.
Dong, Junlin, Hu, Zhenquan, Lu, Tianle, Wang, Shiyu, Zhan, Wenjin, Wu, Chenyang, Yuan, Shuguang, Wang, Bing, Vogel, Horst, Xu, Marc   +9 more
core   +1 more source

Image-Based Screening for the Identification of Novel Proteasome Inhibitors

, 2007
The proteasome is a new, interesting target in cancer drug therapy, and the proteasome inhibitor bortezomib has shown an effect in myeloma patients. It is of interest to efficiently discover and evaluate new proteasome inhibitors.
Linda Rickardson, Larsson, Rolf,, Rolf Larsson, Henrik Lövborg, Malin Wickström, Lövborg, Henrik,, Rickardson, Linda,, Wickström, Malin,   +7 more
core   +1 more source