Results 101 to 110 of about 328,812 (261)

Compound screening: Fresh hunting ground [PDF]

Nature, 2016
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Fast fragment- and compound-screening pipeline at the Swiss Light Source. [PDF]

Acta Crystallogr D Struct Biol, 2022
Kaminski JW, Vera L, Stegmann DP, Vering J, Eris D, Smith KML, Huang CY, Meier N, Steuber J, Wang M, Fritz G, Wojdyla JA, Sharpe ME.   +12 more
europepmc   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

CRISPR/Cas12a combined with recombinase polymerase amplification for rapid and sensitive detection of Vibrio vulnificus in one tube

Acta Biochimica et Biophysica Sinica, 2023
Zhang Xue, Guo Bo, Yang Lihong, Zhao Chenjie, Wang Yue, Tang Yixin, Yang Guang, Wang Pei, Gao Song   +8 more
doaj   +1 more source

Gene mining, recombinant expression and enzymatic characterization of N-acetylglucosamine deacetylase

Türk Biyokimya Dergisi
Glucosamine (GlcN) is an important bioactive substance that is widely used in medicine, dietary supplements, cosmetics, and other fields. The traditional method of producing GlcN is mainly through chitosan hydrolysis catalyzed by strong acid, but this ...
Qiu Min, Dai Xiaohui, Hu Jiliang, Zhang Jianlong, Liu Qiang, Luan Jiabao, Zhou Qingmei, Xia Yu, Zhang Kunxiao, Liu Weiwei   +9 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Liensinine alleviates septic heart injury by targeting inflammation, oxidative stress, apoptosis, and autophagy

Acta Biochimica et Biophysica Sinica, 2023
Zhang Wei, Wang Tianling, Chen Huizhen, Fan Hui, Liu Feixue, Zhang Xiao, Yang Haitao, Li Xueqing, Dong Zibo, Dong Jingquan   +9 more
doaj   +1 more source

Absolute binding free energy calculations improve enrichment of actives in virtual compound screening. [PDF]

Sci Rep, 2022
Feng M, Heinzelmann G, Gilson MK.
europepmc   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source