Results 131 to 140 of about 2,250,906 (262)
High throughput compound screening in neuronal cells identifies statins as activators of ataxin 3 expression. [PDF]
Sci Rep, 2023 Stahl F +5 more
europepmc +1 more source
Automated compound management evolves to meet the drug discovery demands of the future
, 2013 The development of new drugs involves testing hundreds of thousands of compounds, from high throughput screening through to subsequent lead optimization.
Ballard, Sarah +2 more
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
A high-throughput cigarette smoke-treated bronchosphere model for disease-relevant phenotypic compound screening. [PDF]
PLoS One, 2023 Beri P +11 more
europepmc +1 more source
Evaluation report: Limerick awareness campaign, 6th-18th October 2003 / Fiona Tracey
, 2003 Irish Cervical Screening Programme ...
Irish Cervical Screening Programme (ICSP)
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Visit to Breast test Wales, Cardiff
, 1997 Description of a visit to Visit to Breast test Wales, Cardiff by the National Breast Screening ...
National Breast Screening Programme
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source