Results 141 to 150 of about 359,557 (359)

A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers. [PDF]

Nat Commun, 2023
Wranik M, Kepa MW, Beale EV, James D, Bertrand Q, Weinert T, Furrer A, Glover H, Gashi D, Carrillo M, Kondo Y, Stipp RT, Khusainov G, Nass K, Ozerov D, Cirelli C, Johnson PJM, Dworkowski F, Beale JH, Stubbs S, Zamofing T, Schneider M, Krauskopf K, Gao L, Thorn-Seshold O, Bostedt C, Bacellar C, Steinmetz MO, Milne C, Standfuss J.   +29 more
europepmc   +2 more sources

Cancer-associated fibroblasts (CAFs) derived from MFAP2 promote CRC proliferation and metastasis while suppressing CD8+ T cell-mediated antitumor immunity

Cell Death and Disease
Colorectal cancer (CRC) ranks among the most prevalent malignancies of the digestive system, with the intricate tumor immune microenvironment (TIME) emerging as a key determinant of poor prognosis.
Xu Zhang, Yuxiang Fei, Chunqi Xie, Tao Li, Ben Niu, Zihao Yang, Mengwei Song, Fanjun Meng, Hongting Diao, Jing Ji, Qianming Du, Chao Liu   +11 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Assessment of Knowledge and Attitude towards Cervical Cancer Screening among Women in Reproductive Age in Chawama Compound, Lusaka, Zambia [PDF]

, 2023
Voster Nyirenda
openalex   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Curcumin as a promising treatment for pulmonary fibrosis: Mechanism and therapeutic potential

Pharmacological Research - Modern Chinese Medicine
Introduction: Pulmonary fibrosis (PF) is characterized by excessive proliferation of alveolar epithelial cells and fibroblasts, abnormal deposition of fibrous connective tissue, altered alveolar structure, impaired lung function, and increased airway ...
Meigui You, Bin Liu, Aixin Jing, Meiqi Zhang, Qilan Qian, Jing Ji, Yaping Xu, Yujuan Tang   +7 more
doaj   +1 more source

In silico identification of potential drug compound against Peroxisome proliferator-activated receptor-gamma by virtual screening and toxicity studies for the treatment of Diabetic Nephropathy

, 2017
Smrita Singh, Aparajita Mohanty
openalex   +1 more source

Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action

, 2022
Johannes Gubat, Karthik Selvaraju, Linda Sjöstrand, Dhananjay Kumar Singh, Maria V. Turkina, Bernhard Schmierer, Pierre Sabatier, Roman A. Zubarev, Stig Linder, Pádraig D’Arcy   +9 more
openalex   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Development of a fluorescent intensity assay amenable for high-throughput screening for determining 15-lipoxygenase activity

, 2010
15-Lipoxygenase-1 catalyzes the introduction of molecular oxygen into polyunsaturated fatty acids to form a lipid hydroperoxide. The authors have developed an assay for the detection of lipid hydroperoxides formed by human 15-lipoxygenase (15-LO) in ...
Dahlström, M,, Huque-Andersson, Y, Björk, M, Schaal, W, Pelcman, B, Silfverplatz, E, Sanin, A, Johannesson, M, Forsell, PKA, Forsström, D   +9 more
core   +1 more source