Results 141 to 150 of about 328,812 (261)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Development of the reverse genetics system for viral hemorrhagic septicemia virus genotype IVa and its application in antiviral compound screening. [PDF]

Virol Sin
Huang H, Lu X, Hong T, Chen Y, Yi M, Jia K.   +5 more
europepmc   +1 more source

Chemotropism Assays for Plant Symbiosis and Mycoparasitism Related Compound Screening in Trichoderma atroviride. [PDF]

Front Microbiol, 2020
Moreno-Ruiz D, Lichius A, Turrà D, Di Pietro A, Zeilinger S.   +4 more
europepmc   +1 more source

A deep learning framework for high-throughput mechanism-driven phenotype compound screening and its application to COVID-19 drug repurposing. [PDF]

Nat Mach Intell, 2021
Pham TH, Qiu Y, Zeng J, Xie L, Zhang P.
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Correction to "A Structurally Diverse Compound Screening Library to Identify Substrates for Diamine, Polyamine, and Related Acetyltransferases". [PDF]

ACS Omega
Leiva Martel HN, Caro De Silva PL, Painter R, Le VTB, Uychoco P, Figueroa Paniagua D, Endres M, Maltseva N, Joachimiak A, Kuhn ML.   +9 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A high throughput strategy for traditional Chinese medicine active compound screening based on Raman spectroscopy. [PDF]

J Pharm Anal
Tian M, Ma X, Li Y, Zang H, Li L.
europepmc   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out. [PDF]

PLoS One
Wilbie D, Eising S, Amo-Addae V, Walther J, Bosman E, Lei Z, de Jong OG, Molenaar JJ, Mastrobattista E.   +8 more
europepmc   +1 more source