Results 141 to 150 of about 2,250,906 (262)

Fast fragment- and compound-screening pipeline at the Swiss Light Source. [PDF]

Acta Crystallogr D Struct Biol, 2022
Kaminski JW, Vera L, Stegmann DP, Vering J, Eris D, Smith KML, Huang CY, Meier N, Steuber J, Wang M, Fritz G, Wojdyla JA, Sharpe ME.   +12 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Rapid and sensitive detection of Oncorhynchus mykiss adulteration in Salmo salar by recombinase polymerase amplification combined with lateral flow strip

Acta Biochimica et Biophysica Sinica, 2022
Yang Qiankun, Liu Xia, Wang Lei, Yu Guili, Yang Haitao, Fu Hang, Li Xueqing, He Nana, Yu Hong, Dong Jingquan   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Absolute binding free energy calculations improve enrichment of actives in virtual compound screening. [PDF]

Sci Rep, 2022
Feng M, Heinzelmann G, Gilson MK.
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability. [PDF]

Nat Cell Biol
D'Ambrosio M, White MEH, Gavriil ES, Bousset L, Birch J, Gruevska A, Pasquini E, Colucci M, Fong W, Mosole S, Valdata A, Veroutis D, Tyson K, Ranvir V, Prokosch S, Pombo J, Ardisson A, Khadayate S, Young G, Montoya A, Roumelioti G, Houghton J, Lu J, Shliaha PV, De Vita E, Vernia S, Gorgoulis VG, Gallage S, Heikenwälder M, Hall Z, Alimonti A, McNeish IA, Tate EW, Gil J.   +33 more
europepmc   +1 more source

Automated in vivo compound screening with zebrafish and the discovery and validation of PD 81,723 as a novel angiogenesis inhibitor. [PDF]

Sci Rep, 2022
Mauro AN, Turgeon PJ, Gupta S, Brand-Arzamendi K, Chen H, Malone JH, Ng R, Ho K, Dubinsky M, Di Ciano-Oliveira C, Spring C, Plant P, Leong-Poi H, Marshall JC, Marsden PA, Connelly KA, Singh KK.   +16 more
europepmc   +1 more source

Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database

, 2016
Jing Wang,1,* Chunxia Qiao,1,* He Xiao,1 Zhou Lin,1 Yan Li,1 Jiyan Zhang,1 Beifen Shen,1 Tinghuan Fu,2 Jiannan Feng1 1Department of Molecular Immunology, Beijing Institute of Basic Medical Sciences, 2First Affiliated Hospital of PLA General Hospital ...
Li Y, Fu T, Qiao C, Feng J, Zhang J, Xiao H, Lin Z, Shen B, Wang J   +8 more
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source