Results 81 to 90 of about 2,718,187 (290)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A Brand-New Drainage Fluid Predictor, ICAM-1 for Implant Loss After the Immediate Reconstruction of Breast

Breast Cancer: Targets and Therapy
Chenyang He,1,* Yezhen Jiang,2,* Renyang Zhao,1,* Jia Liu,1 Haiying Yang,1 Rongqiang Zhang,3 Yang Zhao1 1The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province ...
He C, Jiang Y, Zhao R, Liu J, Yang H, Zhang R, Zhao Y   +6 more
doaj  

Revisiting Heinz-Lippman disease as a complication of chronic venous insufficiency

Journal of Vascular Surgery Cases and Innovative Techniques
Chronic venous insufficiency with and without ulceration is a common complication of varicose veins. Heinz-Lippmann disease is a potentially underreported complication of chronic venous insufficiency that involves heterotopic ossification of the peri ...
Alisha Oropallo, MD, FACS, Amanda Beneat, MD, Amit Rao, MD, Eric Goodman, MD   +3 more
doaj   +1 more source

To the problems of health management in the context of decentralization of power and spatial planning in the united territorial communities

Zaporožskij Medicinskij Žurnal, 2018
The purpose of the study is to determine the main factors that may adversely affect the spatial planning of the united territorial communities in the management of the healthcare industry. The reform of the administrative-territorial system of Ukraine
A. O. Yanchuk , S. O. Kuznichenko, M. Ye. Okolovych   +2 more
doaj   +1 more source

The Electronic Health Record Scorecard: A Measure of Utilization and Communication Skills [PDF]

, 2016
As the adoption rate of electronic health records (EHRs) in the United States continues to grow, both providers and patients will need to adapt to the reality of a third actor being present during the visit encounter.
Leamon, Ashley E.
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Evaluating Daily Cell-Phone Use in Elderly and its Effect on Lifestyle, Isfahan Comprehensive Health Care Centers. [PDF]

Adv Biomed Res, 2023
Amini Pozveh Z, Shariat A, Tavakoli Moghadam N.   +2 more
europepmc   +1 more source

The Uninsured at the Starting Line: Findings from the 2013 Kaiser Survey of Low-Income Americans and the ACA [PDF]

, 2014
In January 2014, the major coverage provisions of the 2010 Affordable Care Act (ACA) went into full effect. These provisions include the creation of new Health Insurance Marketplaces where low and moderate income families can receive premium tax credits ...
Katherine Young, Rachel Garfield, Rachel Licata   +2 more
core  

The organisation and delivery of health improvement in general practice and primary care: a scoping study [PDF]

, 2015
Background This project examines the organisation and delivery of health improvement activities by and within general practice and the primary health-care team. The project was designed to examine who delivers these interventions, where they are located,
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core   +3 more sources