Results 91 to 100 of about 4,214,030 (374)

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

open access: yesMolecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou   +11 more
wiley   +1 more source

Correction: Most Undirected Random Graphs Are Amplifiers of Selection for Birth-Death Dynamics, but Suppressors of Selection for Death-Birth Dynamics. [PDF]

open access: yesPLoS Computational Biology, 2019
[This corrects the article DOI: 10.1371/journal.pcbi.1004437.].
PLOS Computational Biology Staff
doaj   +1 more source

Correction: A quantitative modelling approach for DNA repair on a population scale.

open access: yesPLoS Computational Biology, 2023
[This corrects the article DOI: 10.1371/journal.pcbi.1010488.].
PLOS Computational Biology Staff
doaj   +1 more source

Application of Computational Biology and Artificial Intelligence Technologies in Cancer Precision Drug Discovery

open access: yesBioMed Research International, 2019
Artificial intelligence (AI) proves to have enormous potential in many areas of healthcare including research and chemical discoveries. Using large amounts of aggregated data, the AI can discover and learn further transforming these data into “usable ...
Nagasundaram Nagarajan   +5 more
semanticscholar   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Correction: Effect of Ionic Diffusion on Extracellular Potentials in Neural Tissue. [PDF]

open access: yesPLoS Computational Biology, 2018
[This corrects the article DOI: 10.1371/journal.pcbi.1005193.].
PLOS Computational Biology Staff
doaj   +1 more source

Metacognition: computation, biology and function [PDF]

open access: yesPhilosophical Transactions of the Royal Society B: Biological Sciences, 2012
Many complex systems maintain a self-referential check and balance. In animals, such reflective monitoring and control processes have been grouped under the rubric of metacognition. In this introductory article to a Theme Issue on metacognition, we review recent and rapidly progressing developments from neuroscience, cognitive psychology, computer ...
Raymond J. Dolan   +4 more
openaire   +3 more sources

Clinical significance of stratifying prostate cancer patients through specific circulating genes

open access: yesMolecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian   +12 more
wiley   +1 more source

Practical Resources for Enhancing the Reproducibility of Mechanistic Modeling in Systems Biology [PDF]

open access: yesarXiv, 2021
Although reproducibility is a core tenet of the scientific method, it remains challenging to reproduce many results. Surprisingly, this also holds true for computational results in domains such as systems biology where there have been extensive standardization efforts. For example, Tiwari et al.
arxiv  

Nano-particle mediated inhibition of Parkinson’s disease using computational biology approach

open access: yesScientific Reports, 2018
Parkinson’s disease (PD) arises as neurodegenerative disorder and characterized by progressive deterioration of motor functions due to forfeiture of dopamine-releasing neurons.
A. Kaushik   +3 more
semanticscholar   +1 more source

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