Results 101 to 110 of about 3,767,744 (333)
Measuring Cellular Biomass Composition for Computational Biology Applications
, 2018 Computational representations of metabolism are increasingly common in medical, environmental, and bioprocess applications. Cellular growth is often an important output of computational biology analyses, and therefore, accurate measurement of biomass ...
A. E. Beck, K. A. Hunt, R. Carlson
semanticscholar +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
PLoS Computational Biology, 2019 [This corrects the article DOI: 10.1371/journal.pcbi.1006378.].
PLOS Computational Biology Staff
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PLoS Comput. Biol., 2017 While women are generally underrepresented in STEM fields, there are noticeable differences between fields. For instance, the gender ratio in biology is more balanced than in computer science. We were interested in how this difference is reflected in the
K. Bonham, Melanie I. Stefan
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Correction: A model for the origin and development of visual orientation selectivity.
PLoS Computational Biology, 2019 [This corrects the article DOI: 10.1371/journal.pcbi.1007254.].
PLOS Computational Biology Staff
doaj +1 more source
Putting benchmarks in their rightful place: The heart of computational biology
PLoS Comput. Biol., 2018 Research in computational biology has given rise to a vast number of methods developed to solve scientific problems. For areas in which many approaches exist, researchers have a hard time deciding which tool to select to address a scientific challenge ...
B. Peters +4 more
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Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Ten Simple Rules for Developing Usable Software in Computational Biology
PLoS Comput. Biol., 2017 The rise of high-throughput technologies in molecular biology has led to a massive amount of publicly available data. While computational method development has been a cornerstone of biomedical research for decades, the rapid technological progress in ...
M. List, Peter Ebert, F. Albrecht
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source