Results 61 to 70 of about 933,309 (343)

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Correction: A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus. [PDF]

PLoS Computational Biology, 2017
[This corrects the article DOI: 10.1371/journal.pcbi.1004919.].
PLOS Computational Biology Staff
doaj   +1 more source

SBML models and MathSBML [PDF]

, 2008
MathSBML is an open-source, freely-downloadable Mathematica package that facilitates working with Systems Biology Markup Language (SBML) models. SBML is a toolneutral,computer-readable format for representing models of biochemical reaction networks ...
Shapiro, B.E., Finney, A., Hucka, M., Bornstein, B., Funahashi, A., Jouraku, A., Keating, S., Le Novere, N., Matthews, J., Schilstra, M.   +9 more
core   +2 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Correction: Emergence of Slow-Switching Assemblies in Structured Neuronal Networks. [PDF]

PLoS Computational Biology, 2017
[This corrects the article DOI: 10.1371/journal.pcbi.1004196.].
PLOS Computational Biology Staff
doaj   +1 more source

Biopython: freely available Python tools for computational molecular biology and bioinformatics [PDF]

, 2009
Summary: The Biopython project is a mature open source international collaboration of volunteer developers, providing Python libraries for a wide range of bioinformatics problems. Biopython includes modules for reading and writing different sequence file
A. Dalke, B. A. Chapman, B. Wilczynski, Bateman, Beaumont, Benson, C. J. Cox, Chaudhuri, F. Kauff, Hamelryck, I. Friedberg, J. T. Chang, M. J. L. de Hoon, P. J. A. Cock, Pearson, Rice, Stajich, T. Antao, T. Hamelryck   +18 more
core   +4 more sources

Limits of computational biology

In Silico Biology, 2015
Are we close to a complete inventory of living processes so that we might expect in the near future to reproduce every essential aspect necessary for life? Or are there mechanisms and processes in cells and organisms that are presently inaccessible to us?
openaire   +4 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Correction: When Optimal Feedback Control Is Not Enough: Feedforward Strategies Are Required for Optimal Control with Active Sensing. [PDF]

PLoS Computational Biology, 2017
[This corrects the article DOI: 10.1371/journal.pcbi.1005190.].
PLOS Computational Biology Staff
doaj   +1 more source

Correction: Hybrid predictive coding: Inferring, fast and slow.

PLoS Computational Biology, 2023
[This corrects the article DOI: 10.1371/journal.pcbi.1011280.].
PLOS Computational Biology Staff
doaj   +1 more source