Results 71 to 80 of about 950,074 (346)

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

SBML models and MathSBML [PDF]

, 2008
MathSBML is an open-source, freely-downloadable Mathematica package that facilitates working with Systems Biology Markup Language (SBML) models. SBML is a toolneutral,computer-readable format for representing models of biochemical reaction networks ...
Shapiro, B.E., Finney, A., Hucka, M., Bornstein, B., Funahashi, A., Jouraku, A., Keating, S., Le Novere, N., Matthews, J., Schilstra, M.   +9 more
core   +2 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Metacognition: computation, biology and function [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2012
Many complex systems maintain a self-referential check and balance. In animals, such reflective monitoring and control processes have been grouped under the rubric of metacognition. In this introductory article to a Theme Issue on metacognition, we review recent and rapidly progressing developments from neuroscience, cognitive psychology, computer ...
Raymond J. Dolan, Chris D. Frith, Chris D. Frith, Chris D. Frith, Stephen M. Fleming   +4 more
openaire   +3 more sources

Chaste: an open source C++ library for computational physiology and biology [PDF]

, 2013
Chaste - Cancer, Heart And Soft Tissue Environment - is an open source C++ library for the computational simulation of mathematical models developed for physiology and biology.
A Cedilnik, A Corrias, A Garny, A Prlić, AC Hindmarsh, AG Fletcher, Alberto Corrias, Alexander G. Fletcher, Andreas Prlic, C Bradley, C Crosnier, C Lopez-Garcia, CH Luo, Christopher J. Arthurs, CJ Arthurs, D Waltemath, D Waltemath, Daniel G. Harvey, David J. Gavaghan, E Pueyo, F Graner, G Karypis, G Wilson, Gary R. Mirams, GR Christie, GR Mirams, GR Mirams, GR Mirams, GR Mirams, GT Eisenhoffer, H Honda, H Perfahl, HJ Snippert, IMM van Leeuwen, J Cooper, J Cooper, J Cooper, J Moreira, J Pitt-Francis, J Southern, J Walmsley, James M. Osborne, James Southern, JM Osborne, Joe Pitt-Francis, Jonathan Cooper, JR Collier, K Beck, K Gima, KM Sanders, M Bernabeu, M Hucka, M Weliky, Megan E. Marsh, Miguel O. Bernabeu, ML Buist, MO Bernabeu, MO Bernabeu, MO Bernabeu, N Le Nov'ere, N Zemzemi, Nejib Zemzemi, P Macklin, P Pathmanathan, P Pathmanathan, P Pathmanathan, P Pathmanathan, P Pathmanathan, Pras Pathmanathan, R Bordas, Rafel Bordas, SA Niederer, Sara-Jane Dunn, SJ Dunn, SJ Dunn, SM Baxter, T Cickovski, Yohan Davit, Z Merali, Z Qu   +79 more
core   +5 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Correction: Accounting for non-stationarity in epidemiology by embedding time-varying parameters in stochastic models. [PDF]

PLoS Computational Biology, 2019
[This corrects the article DOI: 10.1371/journal.pcbi.1006211.].
PLOS Computational Biology Staff
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Correction: The Equivalence of Information-Theoretic and Likelihood-Based Methods for Neural Dimensionality Reduction. [PDF]

PLoS Computational Biology, 2019
[This corrects the article DOI: 10.1371/journal.pcbi.1004141.].
PLOS Computational Biology Staff
doaj   +1 more source