Computational systems biology in disease modeling and control, review and perspectives
npj Systems Biology and Applications, 2022 Omics-based approaches have become increasingly influential in identifying disease mechanisms and drug responses. Considering that diseases and drug responses are co-expressed and regulated in the relevant omics data interactions, the traditional way of ...
Rongting Yue, Abhishek Dutta
semanticscholar +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Correction: Large-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug Repurposing. [PDF]
PLoS Computational Biology, 2017 [This corrects the article DOI: 10.1371/journal.pcbi.1005135.].
PLOS Computational Biology Staff
doaj +1 more source
Biotite: a unifying open source computational biology framework in Python
BMC Bioinformatics, 2018 As molecular biology is creating an increasing amount of sequence and structure data, the multitude of software to analyze this data is also rising.
Patrick Kunzmann, K. Hamacher
semanticscholar +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Correction: Signatures of criticality arise from random subsampling in simple population models. [PDF]
PLoS Computational Biology, 2017 [This corrects the article DOI: 10.1371/journal.pcbi.1005718.].
PLOS Computational Biology Staff
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Correction: Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection. [PDF]
PLoS Computational Biology, 2019 [This corrects the article DOI: 10.1371/journal.pcbi.1004940.].
PLOS Computational Biology Staff
doaj +1 more source
FAIR_Bioinfo: a turnkey training course and protocol for reproducible computational biology [PDF]
, 2021 Thomas Denecker, Claire Toffano‐Nioche
openalex +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source