Results 81 to 90 of about 933,309 (343)
An approach to evolving cell signaling networks in silico [PDF]
, 2006 Cell Signaling Networks(CSN) are complex bio-chemical networks which, through evolution, have become highly efficient for governing critical control processes such as immunological responses, cell cycle control or homeostasis.
Decraene, James +3 more
core
Systems biology in animal sciences [PDF]
, 2011 Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Bannink, A. +4 more
core +3 more sources
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
The computational stance in biology [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2019 The goal of this article is to call attention to, and to express caution about, the extensive use of computation as an explanatory concept in contemporary biology. Inspired by Dennett's ‘intentional stance’ in the philosophy of mind, I suggest that a ‘computational stance’ can be a productive approach to evaluating the value of computational concepts ...
openaire +3 more sources
Molecular Oncology, EarlyView.Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Highlights from the eleventh ISCB Student Council Symposium 2015 [PDF]
, 2016 This report summarizes the scientific content and activities of the annual symposium organized by the Student Council of the International Society for Computational Biology (ISCB), held in conjunction with the Intelligent Systems for Molecular Biology ...
Cuypers, Bart +9 more
core +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Correction: Accounting for non-stationarity in epidemiology by embedding time-varying parameters in stochastic models. [PDF]
PLoS Computational Biology, 2019 [This corrects the article DOI: 10.1371/journal.pcbi.1006211.].
PLOS Computational Biology Staff
doaj +1 more source
Computational system biology [PDF]
Nature Precedings, 2012 AbstractSystems biology is a multi-disciplinary field that deals with mechanisms involved in complex biological processes by considering them as integrated systems of multiple interacting components. The huge amount of data involved in this study necessitates the use of computational tools.
openaire +2 more sources