Results 71 to 80 of about 1,693,695 (274)

Editorial: Quantum computing applications in computational engineering

open access: yesFrontiers in Mechanical Engineering, 2023
René Steijl, Romit Maulik
doaj   +1 more source

Engineering Design under Imprecise Probabilities: Computational Complexity

open access: yesCubo, 2011
In engineering design problems, we want to make sure that a certain quantity c of the designed system lies within given bounds - or at least that the probability of this quantity to be outside these bounds does not exceed a given threshold.
Vladik Kreinovich
doaj  

Topology optimization aided structural design: Interpretation, computational aspects and 3D printing

open access: yesHeliyon, 2017
Construction industry has a major impact on the environment that we spend most of our life. Therefore, it is important that the outcome of architectural intuition performs well and complies with the design requirements.
Georgios Kazakis   +3 more
doaj   +1 more source

Computational simulation for concurrent engineering of aerospace propulsion systems [PDF]

open access: yes
Results are summarized for an investigation to assess the infrastructure available and the technology readiness in order to develop computational simulation methods/software for concurrent engineering.
Chamis, C. C., Singhal, S. N.
core   +1 more source

Extracting falsifiable predictions from sloppy models

open access: yes, 2007
Successful predictions are among the most compelling validations of any model. Extracting falsifiable predictions from nonlinear multiparameter models is complicated by the fact that such models are commonly sloppy, possessing sensitivities to different ...
Casey, Fergal P.   +4 more
core   +1 more source

Computer Aided Engineering [PDF]

open access: yes, 2012
Current solutions in Computer Aided Process Planning (CAPP) can be time consuming, complex and costly to employ and still require the input of an experienced planner. Implementations can require a high degree of configuration, particularly when preexisting knowledge within the company needs to be incorporated.
Srichand Hinduja, Lin Li
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Systematic Applications of Metabolomics in Metabolic Engineering

open access: yesMetabolites, 2012
The goals of metabolic engineering are well-served by the biological information provided by metabolomics: information on how the cell is currently using its biochemical resources is perhaps one of the best ways to inform strategies to engineer a cell to
Robert A. Dromms, Mark P. Styczynski
doaj   +1 more source

A new approach to planning in vitro and in vivo experiments for cardiovascular stents. (1) Fundamentals of design procedures [PDF]

open access: yes, 2000
Copyright @ 2000 Pacini Editore SpAWhile the use of cardiovascular stents is internationally widespread re-stenosis remains a common problem. There are a number of different designs, and this project seeks for design improvements leading to a reduction ...
Atherton, MA, Collins, MW, Doorly, DJ
core  

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