Results 51 to 60 of about 2,977,079 (288)

Discontinuities without discontinuity: The Weakly-enforced Slip Method [PDF]

, 2013
Tectonic faults are commonly modelled as Volterra or Somigliana dislocations in an elastic medium. Various solution methods exist for this problem. However, the methods used in practice are often limiting, motivated by reasons of computational efficiency
Gutiérrez, M. A., Hanssen, R. F., van Brummelen, E. H., van der Zee, K. G., van Zwieten, G. J.   +4 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A posteriori error estimation for model order reduction of parametric systems

Advanced Modeling and Simulation in Engineering Sciences
This survey discusses a posteriori error estimation for model order reduction of parametric systems, including linear and nonlinear, time-dependent and steady systems.
Lihong Feng, Sridhar Chellappa, Peter Benner   +2 more
doaj   +1 more source

Segmentation of Foreground Row Trees in Apple Orchard Images Collected by Ground Vehicles [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
This paper proposes a fully automatic method for the segmentation of foreground row trees in industrial apple orchard images. The segmentation is based on analyzing a combination of a depth map constructed by the Marigold diffusion model and a model ...
M. A. Merzliakova, B. M. Shurygin, A. E. Solovchenko, A. S. Krylov, D. V. Sorokin   +4 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Pairwise ratio transformation of gene expression data leads to improved checkpoint response prediction in lung cancer patients

BMC Bioinformatics
Background Machine learning algorithms identify patterns that would otherwise be difficult to observe in high-dimensional molecular and clinical data.
Jacob Pfeil, Liqian Ma, Hin Ching Lo, Tolga Turan, R. Tyler McLaughlin, Xu Shi, Severiano Villarruel, Stephen Wilson, Xi Zhao, Josue Samayoa, Kyle Halliwill   +10 more
doaj   +1 more source

The Southern Annular Mode and Southern Ocean Surface Westerly Winds in E3SM

Earth and Space Science, 2019
Climate variability and change in the Southern Hemisphere (SH) are influenced by the Southern Annular Mode (SAM) and are closely related to changes in the kinematic properties of the SH surface zonal winds.
Doo Young Lee, Mark R. Petersen, Wuyin Lin   +2 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source