Results 61 to 70 of about 2,977,079 (288)

Discretely Distributed Scheduled Jumps and Interest Rate Derivatives: Pricing in the Context of Central Bank Actions

Economies
Interest rate dynamics are influenced by various economic factors, and central bank meetings play a crucial role concerning this subject matter. This study introduces a novel approach to modeling interest rates, focusing on the impact of central banks ...
Allan Jonathan da Silva, Jack Baczynski
doaj   +1 more source

Observation of large-scale multi-agent based simulations [PDF]

, 2011
The computational cost of large-scale multi-agent based simulations (MABS) can be extremely important, especially if simulations have to be monitored for validation purposes.
D. Wilkins, D.G. Horvitz, G. Kaminka, H. Parunak, N. Gaud, S. Luke, S. Railsback, S.N. Razavi   +7 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Brain Perfusion Analysis Method using Computed Tomography Images [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
In this paper, a multi-stage perfusion calculation pipeline is suggested. It contains preprocessing algorithms for brain tissue segmentation, input artery and output vein detection, a self-supervised neural network for CT image denoising, and ...
E. Khudiakova, A. Gavrilov, A. Krylov
doaj   +1 more source

Persistent meanders and eddies lead to quasi-steady Lagrangian transport patterns in a weak western boundary current

Scientific Reports, 2021
The Brazil Current (BC) is a weak western boundary current flowing along the Southwestern Atlantic Ocean. It is frequently described as a flow with intense mesoscale activity and relatively low volume transport between 5.0 and 10.0 Sv.
M. B. Gouveia, R. Duran, J. A. Lorenzzetti, A. T. Assireu, R. Toste, L. P. de F. Assad, D. F. M. Gherardi   +6 more
doaj   +1 more source

Bayesian computational methods [PDF]

, 2004
If, in the mid 1980?s, one had asked the average statistician about the difficulties of using Bayesian Statistics, his/her most likely answer would have been ?Well, there is this problem of selecting a prior distribution and then, even if one agrees on ...
Robert, Christian P.
core  

SMaSH: A Benchmarking Toolkit for Human Genome Variant Calling

, 2014
Motivation: Computational methods are essential to extract actionable information from raw sequencing data, and to thus fulfill the promise of next-generation sequencing technology. Unfortunately, computational tools developed to call variants from human
Bresler, Ma'ayan, Curtis, Kristal, Hartl, Christopher, Jordan, Michael I., Liptrap, Jesse, Newcomb, Julie, Patterson, David, Song, Yun S., Talwalkar, Ameet, Terhorst, Jonathan   +9 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The numerical solution of the Dirichlet generalized and classical harmonic problems for irregular $ n $-sided pyramidal domains by the method of probabilistic solutions

AIMS Mathematics
This paper describes the application of the method of probabilistic solutions (MPS) to numerically solve the Dirichlet generalized and classical harmonic problems for irregular $ n $-sided pyramidal domains.
Mamuli Zakradze, Zaza Tabagari, Nana Koblishvili, Tinatin Davitashvili, José-María Sánchez-Sáez, Francisco Criado-Aldeanueva   +5 more
doaj   +1 more source

Publisher Correction: Persistent meanders and eddies lead to quasi‑steady Lagrangian transport patterns in a weak western boundary current

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
M. B. Gouveia, R. Duran, J. A. Lorenzzetti, A. T. Assireu, R. Toste, L. P. de F. Assad, D. F. M. Gherardi   +6 more
doaj   +1 more source