Results 41 to 50 of about 3,156,569 (293)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Journal of Rock Mechanics and Geotechnical EngineeringIn this paper, we propose a novel probabilistic method for predicting the undrained bearing capacity of spatially variable soils. Our approach combines a Gaussian process regression (GPR)-based surrogate model with random cell-based smoothed finite ...
H.C. Nguyen +6 more
doaj +1 more source
Cooperation among Virtual Anthropoids in a Complex Environment [PDF]
Interdisciplinary Description of Complex Systems, 2011 This paper presents an agent based model of the evolution of cooperation in a complex environment. Anthropoid agents reproduce sexually, and live in a world where food is irregularly distributed in space and seasonally produced. They can share food, form
Jakson Alves de Aquino
doaj
The ADaptation and Anticipation Model (ADAM) of sensorimotor synchronization
Frontiers in Human Neuroscience, 2013 A constantly changing environment requires precise yet flexible timing of movements. Sensorimotor synchronization (SMS) —the temporal coordination of an action with events in a predictable external rhythm— is a fundamental human skill that contributes to
Maria Christine Van Der Steen +2 more
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Electrical and Kinetic Model of an Atmospheric RF Device for Plasma Aerodynamics Applications
, 2009 The asymmetrically mounted flat plasma actuator is studied using a self-consistent 2-DIM fluid model at atmospheric pressure. The computational model use the drift-diffusion approximation and a simple plasma phenomenological kinetic model.
Martins, Alexandre A. +1 more
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Cell Reports, 2016 Memories are believed to be stored in distributed neuronal assemblies through activity-induced changes in synaptic and intrinsic properties. However, the specific mechanisms by which different memories become associated or linked remain a mystery.
George Kastellakis +2 more
doaj +1 more source
Cosmic Logic: a Computational Model
, 2016 We initiate a formal study of logical inferences in context of the measure problem in cosmology or what we call cosmic logic. We describe a simple computational model of cosmic logic suitable for analysis of, for example, discretized cosmological systems.
Vanchurin, Vitaly
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Postsynaptic signal transduction models for long-term potentiation and depression
Frontiers in Computational Neuroscience, 2010 More than a hundred biochemical species, activated by neurotransmitters binding to transmembrane receptors, are important in long-term potentiation and depression.
Tiina Manninen +5 more
doaj +1 more source