Results 51 to 60 of about 3,156,569 (293)

A computational model of evolution: haploidy versus diploidy [PDF]

, 1999
In this paper, the study of diploidy is introduced like and important mechanism for memory reinforcement in artificial environments where adaptation is very important.
Berlanga de Jesús, Antonio, Isasi, Pedro, Molina López, José Manuel, Sanchis de Miguel, María Araceli   +3 more
core   +1 more source

Sound Computational Interpretation of Formal Encryption with Composed Keys [PDF]

, 2003
The formal and computational views of cryptography have been related by the seminal work of Abadi and Rogaway. In their work, a formal treatment of encryption that uses atomic keys is justified in the computational world.
Corin, R.J., Corin, R.J., Laud, P.
core   +7 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Intrinsic Cellular Properties and Connectivity Density Determine Variable Clustering Patterns in Randomly Connected Inhibitory Neural Networks

Frontiers in Neural Circuits, 2016
The plethora of inhibitory interneurons in the hippocampus and cortex play a pivotal role in generating rhythmic activity by clustering and synchronizing cell firing.
Scott Rich, Victoria Booth, Michal Zochowski   +2 more
doaj   +1 more source

Parallel dynamics and computational complexity of the Bak-Sneppen model

, 2001
The parallel computational complexity of the Bak-Sneppen evolution model is studied. It is shown that Bak-Sneppen histories can be generated by a massively parallel computer in a time that is polylogarithmic in the length of the history. In this parallel
Li, Xuenan, Machta, Jon
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Integrating Immunotherapy With Targeted Therapy: Evaluating Efficacy in NSCLC Treatment Through Computational Analysis of Gene Regulatory Networks

IEEE Access
Non-Small Cell Lung Cancer (NSCLC) remains a leading cause of cancer-related deaths, often characterized by complex mutational landscapes and resistance to monotherapies.
Pranabesh Bhattacharjee, Aditya Lahiri, Tanmay Sindhwani, Norman Peter Reeves, Aniruddha Datta   +4 more
doaj   +1 more source

The mechanisms of potassium loss in acute myocardial ischemia: New insights from computational simulations

Frontiers in Physiology, 2023
Acute myocardial ischemia induces hyperkalemia (accumulation of extracellular potassium), a major perpetrator of lethal reentrant ventricular arrhythmias.
Jose M. Ferrero, Ana Gonzalez-Ascaso, Ana Gonzalez-Ascaso, Jose F. Rodriguez Matas   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Towards an integrative computational model of the guinea pig cardiac myocyte

Frontiers in Physiology, 2012
The local control theory of excitation-contraction (EC) coupling asserts that regulation of calcium (Ca2+) release occurs at the nanodomain level, where openings of single L-type Ca2+ channels (LCCs) trigger openings of small clusters of ryanodine ...
Laura Doyle Gauthier, Joseph L Greenstein, Raimond L Winslow   +2 more
doaj   +1 more source