Results 51 to 60 of about 23,674,484 (362)

Cardiac computational modelling

Revista Española de Cardiología (English Edition), 2021
Cardiovascular diseases currently have a major social and economic impact, constituting one of the leading causes of mortality and morbidity. Personalized computational models of the heart are demonstrating their usefulness both to help understand the mechanisms underlying cardiac disease, and to optimize their treatment and predict the patient's ...
Bragard, Jean R., Camara, Oscar, Echebarria, Blas, Gerardo Giorda, Luca, Pueyo, Esther, Saiz, Javier, Sebastián, Rafael, Soudah, Eduardo, Vázquez, Mariano   +8 more
openaire   +4 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

MECHANICAL FORCES ACCELERATE COLLAGEN DIGESTION BY BACTERIAL COLLAGENASE IN LUNG TISSUE STRIPS

Frontiers in Physiology, 2016
Most tissues in the body are under mechanical tension, and while enzymes mediate many cellular and extracellular processes, the effects of mechanical forces on enzyme reactions in the native extracellular matrix (ECM) are not fully understood.
Eunice Yi, Susumu Sato, Ayuko Takahashi, Harikrishnan Parameswaran, Todd A Blute, Erzsébet Bartolák-Suki, Bela Suki   +6 more
doaj   +1 more source

A computational study on the influence of aortic valve disease on hemodynamics in dilated aorta

Mathematical Biosciences and Engineering, 2020
A computational hemodynamics method was employed to investigate how the morphotype and functional state of aortic valve would affect the characteristics of blood flow in aortas with pathological dilation, especially the intensity and distribution of flow
Lijian Xu, Lekang Yin, Youjun Liu , Fuyou Liang   +3 more
doaj   +1 more source

Dramatis: A Computational Model of Suspense

AAAI Conference on Artificial Intelligence, 2014
We introduce Dramatis, a computational model of suspense based on a reformulation of a psychological definition of the suspense phenomenon. In this reformulation, suspense is correlated with the audience’s ability to generate a plan for the ...
Brian O'Neill, Mark O. Riedl
semanticscholar   +1 more source

On Models of a Nondeterministic Computation [PDF]

, 2009
In this paper we consider a nondeterministic computation by deterministic multi-head 2-way automata having a read-only access to an auxiliary memory. The memory contains additional data (a guess) and computation is successful iff it is successful for some memory content.
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Model of the HVC neural network as a song motor in zebra finch

Frontiers in Computational Neuroscience
The nucleus HVC within the avian song system produces crystalized instructions which lead to precise, learned vocalization in zebra finches (Taeniopygia guttata). This paper proposes a model of the HVC neural network based on the physiological properties
Pan Xia, Henry D. I. Abarbanel
doaj   +1 more source

In silico Interrogation of Insect Central Complex Suggests Computational Roles for the Ellipsoid Body in Spatial Navigation

Frontiers in Behavioral Neuroscience, 2017
The central complex in the insect brain is a composite of midline neuropils involved in processing sensory cues and mediating behavioral outputs to orchestrate spatial navigation. Despite recent advances, however, the neural mechanisms underlying sensory
Vincenzo G. Fiore, Benjamin Kottler, Xiaosi Gu, Frank Hirth   +3 more
doaj   +1 more source

Effects of Choice of Medical Imaging Modalities on a Non-invasive Diagnostic and Monitoring Computational Framework for Patients With Complex Valvular, Vascular, and Ventricular Diseases Who Undergo Transcatheter Aortic Valve Replacement

Frontiers in Bioengineering and Biotechnology, 2021
Due to the high individual differences in the anatomy and pathophysiology of patients, planning individualized treatment requires patient-specific diagnosis. Indeed, hemodynamic quantification can be immensely valuable for accurate diagnosis, however, we
Melissa Baiocchi, Shirley Barsoum, Seyedvahid Khodaei, Jose M. de la Torre Hernandez, Sydney E. Valentino, Emily C. Dunford, Maureen J. MacDonald, Zahra Keshavarz-Motamed, Zahra Keshavarz-Motamed, Zahra Keshavarz-Motamed   +9 more
doaj   +1 more source