Results 61 to 70 of about 23,674,484 (362)

Computer modelling of epilepsy [PDF]

Nature Reviews Neuroscience, 2008
Epilepsy is a complex set of disorders that can involve many areas of the cortex, as well as underlying deep-brain systems. The myriad manifestations of seizures, which can be as varied as déjà vu and olfactory hallucination, can therefore give researchers insights into regional functions and relations.
openaire   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Computational model of neuron-astrocyte interactions during focal seizure generation

Frontiers in Computational Neuroscience, 2012
Empirical research in the last decade revealed that astrocytes can respond to neurotransmitters with Ca2+ elevations and generate feedback signals to neurons which modulate synaptic transmission and neuronal excitability. This discovery changed our basic
Davide eReato, Mario eCammarota, Mario eCammarota, Lucas Cristobal Parra, Giorgio eCarmignoto, Giorgio eCarmignoto   +5 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

A novel end-to-end learning framework for inferring lncRNA-disease associations based on convolution neural network

Frontiers in Genetics
IntroductionIn recent years, lots of computational models have been proposed to infer potential lncRNA-disease associations.MethodsIn this manuscript, we introduced a novel end-to-end learning framework named CNMCLDA, in which, we first adopted two ...
Shunxian Zhou, Sisi Chen, Jinhai Le, Yangtai Xu, Lei Wang   +4 more
doaj   +1 more source

Acetylcholine-Based Entropy in Response Selection: A Model of How Striatal Interneurons Modulate Exploration, Exploitation, and Response Variability in Decision Making

Frontiers in Neuroscience, 2012
The basal ganglia play a fundamental role in decision making. Their contribution is typically modeled within a reinforcement learning framework, with the basal ganglia learning to select the options associated with highest value and their dopamine inputs
Andrea eStocco
doaj   +1 more source

SWISS-MODEL: homology modelling of protein structures and complexes

Nucleic Acids Res., 2018
Homology modelling has matured into an important technique in structural biology, significantly contributing to narrowing the gap between known protein sequences and experimentally determined structures. Fully automated workflows and servers simplify and
A. Waterhouse, Martino Bertoni, S. Bienert, G. Studer, G. Tauriello, Rafal Gumienny, F. Heer, T. Beer, Christine Rempfer, L. Bordoli, R. Lepore, T. Schwede   +11 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The 2N-ary choice tree model for N-alternative preferential choice

Frontiers in Psychology, 2012
The 2N-ary choice tree model accounts for response times and choice probabilities in multi-alternative preferential choice. It implements pairwise comparison of alternatives on weighted attributes into an information sampling process which, in turn ...
Lena Maria Wollschläger, Adele eDiederich   +1 more
doaj   +1 more source

Tinnitus with a Normal Audiogram: Physiological Evidence for Hidden Hearing Loss and Computational Model

Journal of Neuroscience, 2011
Ever since Pliny the Elder coined the term tinnitus, the perception of sound in the absence of an external sound source has remained enigmatic. Traditional theories assume that tinnitus is triggered by cochlear damage, but many tinnitus patients present ...
R. Schaette, D. McAlpine
semanticscholar   +1 more source