Results 61 to 70 of about 3,156,569 (293)

A Computational Model of Working Memory Based on Spike-Timing-Dependent Plasticity

Frontiers in Computational Neuroscience, 2021
Working memory is closely involved in various cognitive activities, but its neural mechanism is still under exploration. The mainstream view has long been that persistent activity is the neural basis of working memory, but recent experiments have ...
Qiu-Sheng Huang, Hui Wei
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection

eLife
Locomotion is controlled by spinal circuits that interact with supraspinal drives and sensory feedback from the limbs. These sensorimotor interactions are disrupted following spinal cord injury. The thoracic lateral hemisection represents an experimental
Ilya A Rybak, Natalia A Shevtsova, Johannie Audet, Sirine Yassine, Sergey N Markin, Boris I Prilutsky, Alain Frigon   +6 more
doaj   +1 more source

Computational models of neurophysiological correlates of tinnitus

Frontiers in Systems Neuroscience, 2012
The understanding of tinnitus has progressed considerably in the past decade, but the details of the mechanisms that give rise to this phantom perception of sound without a corresponding acoustic stimulus have not been pinpointed yet.
Roland eSchaette, Richard eKempter
doaj   +1 more source

A Closed-Loop Modeling Framework for Cardiac-to-Coronary Coupling

Frontiers in Physiology, 2022
The mechanisms by which cardiac mechanics effect coronary perfusion (cardiac-to-coronary coupling) remain incompletely understood. Several coronary models have been proposed to deepen our understanding of coronary hemodynamics, but possibilities for in ...
Anneloes G. Munneke, Joost Lumens, Theo Arts, Tammo Delhaas   +3 more
doaj   +1 more source

Microscopic Computational Model of a Superfluid

, 2009
A finite one-dimensional microscopic model of a superfulid is presented. The model consists of interacting Bose particles with an additional impurity particle confined to a ring.
Novikov, Alexey, Ovchinnikov, Mikhail
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

(Mal)adaptive Mentalizing in the Cognitive Hierarchy, and Its Link to Paranoia

Computational Psychiatry
Humans need to be on their toes when interacting with competitive others to avoid being taken advantage of. Too much caution out of context can, however, be detrimental and produce false beliefs of intended harm.
Nitay Alon, Lion Schulz, Vaughan Bell, Michael Moutoussis, Peter Dayan, Joseph M. Barnby   +5 more
doaj   +1 more source

Detecting Global form: separate processes required for Glass and Radial Frequency patterns.

Frontiers in Computational Neuroscience, 2013
Global processing of form information has been studied extensively using both Glass and radial frequency patterns. Models, with common early stages, have been proposed for the detection of properties of both pattern types but human performance has not ...
David Russel Badcock, Renita A Almeida, J Edwin Dickinson   +2 more
doaj   +1 more source

A Computational Model for Quantum Measurement

, 2003
Is the dynamical evolution of physical systems objectively a manifestation of information processing by the universe? We find that an affirmative answer has important consequences for the measurement problem.
Srikanth, R.
core   +1 more source