Results 31 to 40 of about 721,084 (255)

Optimization of Human Neural Progenitor Cells for an Imaging-Based High-Throughput Phenotypic Profiling Assay for Developmental Neurotoxicity Screening

Frontiers in Toxicology, 2022
Studies in in vivo rodent models have been the accepted approach by regulatory agencies to evaluate potential developmental neurotoxicity (DNT) of chemicals for decades. These studies, however, are inefficient and cannot meet the demand for the thousands
Megan Culbreth, Johanna Nyffeler, Johanna Nyffeler, Clinton Willis, Joshua A. Harrill   +4 more
doaj   +1 more source

Proteomics for systems toxicology

Computational and Structural Biotechnology Journal, 2014
Current toxicology studies frequently lack measurements at molecular resolution to enable a more mechanism-based and predictive toxicological assessment.
Bjoern Titz, Ashraf Elamin, Florian Martin, Thomas Schneider, Sophie Dijon, Nikolai V. Ivanov, Julia Hoeng, Manuel C. Peitsch   +7 more
doaj   +1 more source

Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility Differences in a Genetically Diverse Zebrafish Model

Frontiers in Toxicology, 2022
Understanding the mechanisms behind chemical susceptibility differences is key to protecting sensitive populations. However, elucidating gene-environment interactions (GxE) presents a daunting challenge.
Dylan J. Wallis, Jane La Du, Preethi Thunga, Daniel Elson, Lisa Truong, Siva K. Kolluri, Robyn L. Tanguay, David M. Reif   +7 more
doaj   +1 more source

Developing integrated PBPK/PD coupled mechanistic pathway model (miRNA-BDNF): An approach towards system toxicology [PDF]

, 2017
Integration of a dynamic signal transduction pathway into the tissue dosimetry model is a major advancement in the area of computational toxicology. This paper illustrates the ways to incorporate the use of existing system biological model in the field ...
M Schuhmacher, RP Sharma, V Kumar
core   +1 more source

Mapping Drug Physico-Chemical Features to Pathway Activity Reveals Molecular Networks Linked to Toxicity Outcome [PDF]

, 2010
The identification of predictive biomarkers is at the core of modern toxicology. So far, a number of approaches have been proposed. These rely on statistical inference of toxicity response from either compound features (i.e., QSAR), in vitro cell based ...
A Conesa, A Doi, A Vedani, C Klaassen, C Merlot, C Pereira, D Dix, E Lobenhofer, F Dieterle, Fernando Ortega, Francesco Falciani, G Steiner, H Geng, I Tetko, J Chipman, J Freeman, J Gower, J Waring, J. Kevin Chipman, K Sameith, L Mayr, M Fielden, N Cariello, P Bushel, P Vayer, Philipp Antczak, R Amin, R Judson, R Thomas, Raya Khanin, S Kong, S Raychaudhuri, S Song, S Song, V Trevino, W Schoeppe, Y Benjamini   +36 more
core   +8 more sources

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

Journal of Cheminformatics, 2017
Despite an abundance of online databases providing access to chemical data, there is increasing demand for high-quality, structure-curated, open data to meet the various needs of the environmental sciences and computational toxicology communities.
Antony J. Williams, Christopher M. Grulke, Jeff Edwards, Andrew D. McEachran, Kamel Mansouri, Nancy C. Baker, Grace Patlewicz, Imran Shah, John F. Wambaugh, Richard S. Judson, Ann M. Richard   +10 more
doaj   +1 more source

A Survey of Computational Toxicology Approaches [PDF]

Kafrelsheikh Journal of Information Sciences, 2021
Medications are a particular kind of chemicals that are considered essential for toxicity screening in contrast to those substances that contribute to the environment. In the development and production phases, toxicity is still the reason for a great number of candidate failures for new medicines.
openaire   +1 more source

Assembly and Curation of Lists of Per- and Polyfluoroalkyl Substances (PFAS) to Support Environmental Science Research

Frontiers in Environmental Science, 2022
Per- and polyfluoroalkyl substances (PFAS) are a class of man-made chemicals of global concern for many health and regulatory agencies due to their widespread use and persistence in the environment (in soil, air, and water), bioaccumulation, and toxicity.
Antony J. Williams, Linda G. T. Gaines, Christopher M. Grulke, Charles N. Lowe, Gabriel F. B. Sinclair, Vicente Samano, Inthirany Thillainadarajah, Bryan Meyer, Grace Patlewicz, Ann M. Richard   +9 more
doaj   +1 more source

The Salmonella Mutagenicity Assay: The Stethoscope of Genetic Toxicology for the 21st Century [PDF]

, 2015
Objectives: According to the 2007 National Research Council report Toxicology for the Twenty-First Century, modern methods (e.g., "omics," in vitro assays, high-throughput testing, computational methods) will lead to the emergence of a new approach to ...
Ashby J, Ashby J, Burdette WJ, Cerná M, Claxton LD, David M. DeMarini, de Serres F, Garner RC, Gisela de A. Umbuzeiro, Göggelmann W, Hayashida S, Holly EA, Kihlman BA, Larry D. Claxton, Miller JA, National Research Council, Piegorsch WW, Poth A, Ray VA, Rinkus SJ, Schoonen WGEJ, Sugimura T, Tordaro GJ, Umbuzeiro Gde A, Ward WO, Weinberg F, Zimmermann FK   +26 more
core   +2 more sources

Systems biology and synthetic biology: A new epoch for toxicology research [PDF]

, 2014
Copyright © 2015 Mark T. Mc Auley et al. This is an open access article distributed under the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Choi, Hyunok, Mc Auley, Mark T., Miller, Veronica M., Mooney, Kathleen M., Paul, Emily   +4 more
core   +6 more sources